{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T21:31:52Z","timestamp":1692653512561},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,3,1]]},"abstract":"<jats:p>1. The aim of the study was to examine the responses of plasma glucose, C-peptide immunoreactivity (CPR) and total immunoreactive insulin (IRI) to a standard meal in heroin addicts, since the presence of immunoreactive \u03b2-endorphin has been demonstrated in human endocrine pancreas.<\/jats:p>\n               <jats:p>2. Ten heroin addicts and 10 control subjects participated in the study. The addicts had been taking heroin (from 0.5 to 2 g\/day) for at least 2 months and they had no detectable diseases.<\/jats:p>\n               <jats:p>3. After a 12 h fast, each subject received a standard meal; blood samples were taken at \u2212 15, 0, 15, 30, 60 and 120 min to determine glucose, CPR and IRI. Calculation of the CPR\/IRI molar ratio was used as a semiquantitative estimation of the hepatic extraction of insulin.<\/jats:p>\n               <jats:p>4. No difference in plasma glucose was observed between the groups. Addicts had lower CPR than normals at 15, 30 and 120 min (P &amp;lt; 0.01). On the contrary, IRI was higher in addicts than in normals (P &amp;lt; 0.05 at \u2212 15 and 0 min, P &amp;lt; 0.01 at 15, 30 and 60 min), except at 120 min. The CPR\/IRI molar ratio was lower in addicts (P &amp;lt; 0.01).<\/jats:p>\n               <jats:p>5. Heroin addiction seems to produce a \u03b2-cell failure and contemporaneously a state of hyperinsulinaemia; blood glucose remains in the normal range.<\/jats:p>\n               <jats:p>6. We conclude that chronic heroin addiction may produce a change in the rate of hepatic extraction of insulin.<\/jats:p>","DOI":"10.1042\/cs0740283","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:18:52Z","timestamp":1438946332000},"page":"283-288","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of heroin addiction on the responses of glucose, C-peptide and insulin to a standard meal"],"prefix":"10.1042","volume":"74","author":[{"given":"R.","family":"Zandomeneghi","sequence":"first","affiliation":[{"name":"1Istituto di Clinica Medica, Patologia Speciale Medica, University of Modena, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Luciani","sequence":"additional","affiliation":[{"name":"2Istituto di Clinica Medica, Patologia Speciale Medica, University of Modena, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Massari","sequence":"additional","affiliation":[{"name":"3Istituto di Clinica Medica, Patologia Speciale Medica, University of Modena, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Montanari","sequence":"additional","affiliation":[{"name":"4Istituto di Clinica Medica, Patologia Speciale Medica, University of Modena, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Pavesi","sequence":"additional","affiliation":[{"name":"5Istituto di Clinica Medica, Patologia Speciale Medica, University of Modena, Modena, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/74\/3\/283\/458902\/cs0740283.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/74\/3\/283\/458902\/cs0740283.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:23:10Z","timestamp":1638397390000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/74\/3\/283\/74301\/Effects-of-heroin-addiction-on-the-responses-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0740283","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,3,1]]}}}