{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:50:38Z","timestamp":1760889038587},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,4,1]]},"abstract":"<jats:p>1. This study analyses whole blood in acutely unclipped one-kidney, one-clip (1K,1C) hypertensive rats for the presence of platelet-activating factor (PAF), a potent vasodilator and a putative mediator of the rapid blood pressure (BP) fall seen after unclipping.<\/jats:p>\n               <jats:p>2. Hypertensive 1K,1C rats were anaesthetized and a carotid and jugular cannula were inserted for BP measurement and anaesthetic infusion respectively. After a stable level of anaesthesia was attained, the constrictive clip was removed and BP was recorded for 30 min.<\/jats:p>\n               <jats:p>3. Blood was drawn from the aorta directly into ice-cold acetone. The extract was analysed for PAF by a bioassay using 5-hydroxy-[14C]tryptamine-labelled platelets.<\/jats:p>\n               <jats:p>4. Rats which showed a BP fall had elevated levels of PAF [55 \u00b1 6 (sem) pg\/ml] when compared with those with no fall in BP [26 \u00b1 7 (sem) pg\/ml] (P &amp;lt; 0.01).<\/jats:p>\n               <jats:p>5. This supports the hypothesis that activation of PAF biosynthesis may be a mechanism contributing to the fall in BP seen after unclipping the 1K,1C hypertensive rat.<\/jats:p>","DOI":"10.1042\/cs0740393","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:18:52Z","timestamp":1438946332000},"page":"393-396","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Increased levels of platelet-activating factor (1-<i>O<\/i>-alkyl-2-acetylglycerophosphocholine) in blood after reversal of renal clip hypertension in the rat"],"prefix":"10.1042","volume":"74","author":[{"given":"H. M.","family":"McGowan","sequence":"first","affiliation":[{"name":"University Department of Medicine, Royal Perth Hospital, Perth, Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Vandongen","sequence":"additional","affiliation":[{"name":"University Department of Medicine, Royal Perth Hospital, Perth, Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. D.","family":"Kelly","sequence":"additional","affiliation":[{"name":"University Department of Medicine, Royal Perth Hospital, Perth, Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. J.","family":"Hill","sequence":"additional","affiliation":[{"name":"University Department of Medicine, Royal Perth Hospital, Perth, Western Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/74\/4\/393\/458962\/cs0740393.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/74\/4\/393\/458962\/cs0740393.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:23:07Z","timestamp":1638397387000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/74\/4\/393\/74297\/Increased-levels-of-platelet-activating-factor-1-O"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1988,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0740393","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,4,1]]}}}