{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:50:56Z","timestamp":1770486656007,"version":"3.49.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,5,1]]},"abstract":"<jats:p>1. Sedatives such as the benzodiazepines and alcohol reduce upper airway muscle activity. We hypothesized that a sedating antihypertensive, \u03b1-methyldopa, might have similar effects. To investigate this hypothesis we studied the effect of \u03b1-methyldopa on alae nasi electromyographic (EMG) activity during hypercapnia.<\/jats:p>\n               <jats:p>2. We studied ten healthy subjects and three subjects with obstructive sleep apnoea during CO2-stimulated breathing. In a preliminary study four subjects demonstrated a fall in alae nasi EMG activity 4 h after the ingestion of 500 mg of \u03b1-methyldopa during CO2 rebreathing.<\/jats:p>\n               <jats:p>3. In six additional normal subjects and three subjects with obstructive sleep apnoea, we studied the alae nasi EMG activity during steady-state hypercapnia with PCO2 held constant 5 torr (0.7 kPa) above baseline. On 2 separate days we studied subjects before and 2 h after they had ingested 750 mg of \u03b1-methyldopa or placebo.<\/jats:p>\n               <jats:p>4. In the normal subjects the mean alae nasi EMG activity fell by 34% 2 h after ingestion of \u03b1-methyldopa (P &amp;lt; 0.05) without a change in other ventilatory parameters.<\/jats:p>\n               <jats:p>5. In the sleep apnoea group the individual mean alae nasi EMG activity fell 16\u201349%, with ventilation and tidal volume falling in one patient.<\/jats:p>\n               <jats:p>6. We conclude that \u03b1-methyldopa selectively reduces upper airway motor activity.<\/jats:p>","DOI":"10.1042\/cs0740547","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:18:52Z","timestamp":1438946332000},"page":"547-551","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["<i>\u03b1<\/i>-Methyldopa selectively reduces alae nasi activity"],"prefix":"10.1042","volume":"74","author":[{"given":"K. C.","family":"Lahive","sequence":"first","affiliation":[{"name":"Charles A. Dana Research Institute and Harvard-Thorndike Laboratory of Beth Israel Hospital, Departments of Medicine, Beth Israel Hospital and Harvard Medical School, and Sleep Disorders Unit, Beth Israel Hospital, Boston, Massachusetts, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Charles A. Dana Research Institute and Harvard-Thorndike Laboratory of Beth Israel Hospital, Departments of Medicine, Beth Israel Hospital and Harvard Medical School, and Sleep Disorders Unit, Beth Israel Hospital, Boston, Massachusetts, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. E.","family":"Weinberger","sequence":"additional","affiliation":[{"name":"Charles A. Dana Research Institute and Harvard-Thorndike Laboratory of Beth Israel Hospital, Departments of Medicine, Beth Israel Hospital and Harvard Medical School, and Sleep Disorders Unit, Beth Israel Hospital, Boston, Massachusetts, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/74\/5\/547\/459038\/cs0740547.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/74\/5\/547\/459038\/cs0740547.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:25:18Z","timestamp":1638397518000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/74\/5\/547\/74405\/Methyldopa-selectively-reduces-alae-nasi-activity"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1988,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0740547","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,5,1]]}}}