{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:56:08Z","timestamp":1760622968676},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,7,1]]},"abstract":"<jats:p>1. The accumulation in the lung of the plasma protein transferrin was determined in 44 patients with widespread pulmonary infiltrates of various causes and in 11 healthy volunteers using a double-isotope method based on labelling in vivo of circulating transferrin with indium and erythrocytes with technetium.<\/jats:p>\n               <jats:p>2. In 22 patients meeting criteria for the adult respiratory distress syndrome (ARDS) the mean transferrin accumulation rate was threefold greater (P &amp;lt; 0.005) than in 22 patients not meeting these criteria, although most possessed an appropriate risk factor for ARDS, in addition to extensive radiographic changes.<\/jats:p>\n               <jats:p>3. The double-isotope method did not completely separate patients with ARDS from those not meeting the criteria or from control subjects and cannot be considered a diagnostic test for the condition. Statistically significant rates of transferrin accumulation, however, occurred more frequently in patients with ARDS (82%) than in controls (64%) or in those without ARDS (59%).<\/jats:p>","DOI":"10.1042\/cs0750047","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:21:31Z","timestamp":1438946491000},"page":"47-52","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["An assessment of a double-isotope method for the detection of transferrin accumulation in the lungs of patients with widespread pulmonary infiltrates"],"prefix":"10.1042","volume":"75","author":[{"given":"G. M.","family":"Rocker","sequence":"first","affiliation":[{"name":"Respiratory Medicine Unit, Nottingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Pearson","sequence":"additional","affiliation":[{"name":"Department of Medical Physics, City Hospital, Nottingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Pathology Department, University of Nottingham, Nottingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Shale","sequence":"additional","affiliation":[{"name":"Respiratory Medicine Unit, Nottingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/75\/1\/47\/459096\/cs0750047.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/75\/1\/47\/459096\/cs0750047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:25:21Z","timestamp":1638397521000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/75\/1\/47\/74408\/An-assessment-of-a-double-isotope-method-for-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0750047","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,7,1]]}}}