{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:29:10Z","timestamp":1761823750941},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,7,1]]},"abstract":"<jats:p>1. In conscious rabbits, intravenous morphine (3 mg\/kg) caused hypertension, bradycardia, hyperglycaemia and sedation. These changes were accompanied by large increases in plasma adrenaline and smaller increases in plasma noradrenaline.<\/jats:p>\n               <jats:p>2. These effects of morphine were prevented by intravenous naloxone, demonstrating their dependence on stimulation of opiate receptors.<\/jats:p>\n               <jats:p>3. Pretreatment with the antihistamines cimetidine and chlorpheniramine enhanced the morphine-induced rise in blood pressure, excluding a role for histamine release in the hypertensive action of morphine.<\/jats:p>\n               <jats:p>4. The centrally acting \u03b12-adrenergic agonist clonidine prevented the morphine-induced hypertension and rise in plasma catecholamines, suggesting that these effects are exerted via central pathways. Clonidine alone reduced blood pressure and heart rate and produced hyperglycaemia.<\/jats:p>\n               <jats:p>5. \u03b1-Adrenergic blockade with phenoxybenzamine reduced the increase in blood pressure after morphine, although the increase in plasma catecholamines was augmented.<\/jats:p>\n               <jats:p>6. Pentobarbitone anaesthesia prevented the morphine-induced cardiovascular changes, the increase in plasma catecholamines and the hyperglycaemia.<\/jats:p>\n               <jats:p>7. These findings indicate, that in conscious rabbits, morphine induces hypertension by stimulation of opiate receptors leading to increased sympatho-adrenal activity. The hyperglycaemia appears to be in response to secretion of adrenaline. These effects probably result from a central action of morphine.<\/jats:p>","DOI":"10.1042\/cs0750071","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:21:31Z","timestamp":1438946491000},"page":"71-77","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Intravenous morphine causes hypertension, hyperglycaemia and increases sympatho-adrenal outflow in conscious rabbits"],"prefix":"10.1042","volume":"75","author":[{"given":"Clive N.","family":"May","sequence":"first","affiliation":[{"name":"1Medical Unit, St Mary's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian W.","family":"Ham","sequence":"additional","affiliation":[{"name":"2Medical Unit, St Mary's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten E.","family":"Heslop","sequence":"additional","affiliation":[{"name":"3Medical Unit, St Mary's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances A.","family":"Stone","sequence":"additional","affiliation":[{"name":"4Medical Unit, St Mary's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher J.","family":"Mathias","sequence":"additional","affiliation":[{"name":"5Medical Unit, St Mary's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/75\/1\/71\/459151\/cs0750071.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/75\/1\/71\/459151\/cs0750071.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:25:38Z","timestamp":1638397538000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/75\/1\/71\/74420\/Intravenous-morphine-causes-hypertension"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0750071","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,7,1]]}}}