{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T23:05:30Z","timestamp":1765667130588},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,12,1]]},"abstract":"<jats:p>1. The present study examined the effect of an infusion of the dipeptide alanylglutamine or of the corresponding amino acids alanine and glutamine in equimolar amounts (10 \u03bcmol min\u22121 kg\u22121) on the canine hindlimb exchange of alanine and glutamine in the post-operative anaesthetized dog. In contrast to glutamine, the dipeptide alanylglutamine is stable in aqueous solution and therefore would be a suitable substrate for parenteral nutrition.<\/jats:p>\n               <jats:p>2. The infusion of alanylglutamine increased (a) the arterial concentration of alanylglutamine to a plateau level (120 \u00b1 9.5 \u03bcmol\/l, mean \u00b1 sem) 20 min after start of the infusion, (b) the mean arterial alanine concentration from 761 \u00b1 42 to a plateau of 1500\u20131700 \u03bcmol\/l (P &amp;gt; 0.01) and (c) the arterial glutamine concentration from 407 \u00b1 51 to a plateau of 1050\u20131500 \u03bcmol\/l (P &amp;gt; 0.01). Alanine and glutamine levels were slightly higher (14% and 26%, respectively, NS) in the group receiving the equimolar amount of alanine and glutamine.<\/jats:p>\n               <jats:p>3. Infusion of alanylglutamine for 1 h abolished the net efflux of glutamine (from \u22120.80 \u00b1 0.1 to \u22120.03 \u00b1 0.2 \u03bcmol min\u22121 kg\u22121; P &amp;gt;0.05) and invoked a net influx of alanine (from \u22120.50 \u00b1 0.19 to + 0.27 \u00b1 0.14 \u03bcmol min\u22121 kg\u22121; P &amp;gt; 0.01). These changes were similar to those achieved when the two amino acids were infused.<\/jats:p>\n               <jats:p>4. This study demonstrates that during short-term administration of alanylglutamine or of the corresponding amino acids the nitrogen release from the hindlimb of the anaesthetized post-operative dog via alanine and glutamine is reduced.<\/jats:p>","DOI":"10.1042\/cs0750641","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:21:31Z","timestamp":1438946491000},"page":"641-648","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Alanylglutamine reduces muscle loss of alanine and glutamine in post-operative anaesthetized dogs"],"prefix":"10.1042","volume":"75","author":[{"given":"Erich","family":"Roth","sequence":"first","affiliation":[{"name":"1st Surgical University Clinic, Department of Surgical Pathophysiology, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Karner","sequence":"additional","affiliation":[{"name":"1st Surgical University Clinic, Department of Surgical Pathophysiology, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnter","family":"Ollenschl\u00e4ger","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, University of Cologne, Cologne, F.R.G."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Karner","sequence":"additional","affiliation":[{"name":"1st Surgical University Clinic, Department of Surgical Pathophysiology, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Simmel","sequence":"additional","affiliation":[{"name":"1st Surgical University Clinic, Department of Surgical Pathophysiology, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"F\u00fcrst","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry and Nutrition, University of Hohenheim, Hohenheim, F.R.G."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Funovics","sequence":"additional","affiliation":[{"name":"1st Surgical University Clinic, Department of Surgical Pathophysiology, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/75\/6\/641\/459450\/cs0750641.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/75\/6\/641\/459450\/cs0750641.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:26:36Z","timestamp":1638397596000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/75\/6\/641\/74473\/Alanylglutamine-reduces-muscle-loss-of-alanine-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1988,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0750641","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,12,1]]}}}