{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:16:11Z","timestamp":1759331771925},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,1,1]]},"abstract":"<jats:p>1. The serum concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D were measured in 44 patients with primary hyperparathyroidism.<\/jats:p>\n               <jats:p>2. In 14 patients the serum concentration of 1,25-dihydroxyvitamin D was greater than normal (142\u2013337 pmol\/l). One patient had a subnormal concentration of 1,25-dihydroxyvitamin D (36 pmol\/l) but no other evidence of vitamin D deficiency.<\/jats:p>\n               <jats:p>3. The possible biological determinants of the serum concentration of 1,25-dihydroxyvitamin D were sought by multivariate analysis of relevant variables. The serum concentration of 1,25-dihydroxyvitamin D was found to be significantly and positively correlated with the serum concentrations of 25-hydroxyvitamin D (P &amp;lt; 0.001) and parathyroid hormone (P &amp;lt; 0.003), and with the glomerular filtration rate (P &amp;lt; 0.03), and negatively correlated with the serum concentrations of calcium (P &amp;lt; 0.02) and phosphate (P = 0.055) (multiple R = 0.638,P &amp;lt; 0.002).<\/jats:p>\n               <jats:p>4. In primary hyperparathyroidism the major determinant of serum 1,25-dihydroxyvitamin D is the availability of precursor 25-hydroxyvitamin D.<\/jats:p>\n               <jats:p>5. The finding that serum 1,25-dihydroxyvitamin D is commonly normal in patients with primary hyperparathyroidism despite an adequate state of vitamin D nutrition, can be explained in terms of the constraining influences of hypercalcaemia and variable degrees of renal dysfunction on the biosynthesis of 1,25-dihydroxyvitamin D.<\/jats:p>","DOI":"10.1042\/cs0760081","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:27:12Z","timestamp":1438946832000},"page":"81-86","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Determinants of the serum concentration of 1,25-dihydroxyvitamin D in primary hyperparathyroidism"],"prefix":"10.1042","volume":"76","author":[{"given":"B. C.","family":"Lalor","sequence":"first","affiliation":[{"name":"University Department of Medicine, Royal Infirmary, Manchester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. B.","family":"Mawer","sequence":"additional","affiliation":[{"name":"University Department of Medicine, Royal Infirmary, Manchester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Davies","sequence":"additional","affiliation":[{"name":"University Department of Medicine, Royal Infirmary, Manchester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Lumb","sequence":"additional","affiliation":[{"name":"University Department of Medicine, Royal Infirmary, Manchester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Computational Group, Royal Infirmary, Manchester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. H.","family":"Adams","sequence":"additional","affiliation":[{"name":"University Department of Medicine, Royal Infirmary, Manchester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/76\/1\/81\/459691\/cs0760081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/76\/1\/81\/459691\/cs0760081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:27:53Z","timestamp":1638397673000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/76\/1\/81\/74599\/Determinants-of-the-serum-concentration-of-1-25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0760081","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,1,1]]}}}