{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:19:57Z","timestamp":1758280797192},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,4,1]]},"abstract":"<jats:p>1. The plasma concentration of inactive renin was two-to three-fold higher in male than in female mice independently of whether mice of strains with low (BALB\/c) or high (Theiller) content of active renin in the submandibular salivary glands were studied.<\/jats:p>\n               <jats:p>2. Removal of the submandibular glands did not affect the high plasma concentration of inactive renin in male mice.<\/jats:p>\n               <jats:p>3. Inactive plasma renin decreased over several days after castration of normal and sialoadenectomized male mice to the same levels as those found in normal female mice.<\/jats:p>\n               <jats:p>4. Treatment of these castrated male mice with testosterone increased and normalized inactive plasma renin independently of whether the submandibular glands had been previously removed or not.<\/jats:p>\n               <jats:p>5. Testosterone treatment of sialoadenectomized female mice increased inactive renin to the same levels as those found in normal male mice.<\/jats:p>\n               <jats:p>6. Our findings suggest that the sex difference in inactive plasma renin in mice may be explained by an increased secretion of inactive renin in male mice stimulated by androgens.<\/jats:p>\n               <jats:p>7. Since we have recently found that inactive plasma renin in male mice is mainly of renal origin, this increased secretion is most likely located to the kidneys.<\/jats:p>","DOI":"10.1042\/cs0760439","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:27:12Z","timestamp":1438946832000},"page":"439-446","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Inactive plasma renin exhibits sex difference in mice"],"prefix":"10.1042","volume":"76","author":[{"given":"Arne H\u00f8j","family":"Nielsen","sequence":"first","affiliation":[{"name":"Institute of Biochemistry, The Royal Dental College, and The Medical School, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Johannessen","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, The Royal Dental College, and The Medical School, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knud","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, The Royal Dental College, and The Medical School, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/76\/4\/439\/459783\/cs0760439.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/76\/4\/439\/459783\/cs0760439.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:28:40Z","timestamp":1638397720000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/76\/4\/439\/74721\/Inactive-plasma-renin-exhibits-sex-difference-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0760439","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,4,1]]}}}