{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:31:06Z","timestamp":1762252266164},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,6,1]]},"abstract":"<jats:p>1. Type 1b and type 1c glycogen-storage disease are caused respectively by deficiencies of the glucose-6-phosphate translocase and the phosphate\/pyrophosphate translocase of the human hepatic microsomal glucose-6-phosphatase system.<\/jats:p>\n               <jats:p>2. Current methods of unequivocally diagnosing type 1b and type 1c glycogen storage disease are indirect and complex.<\/jats:p>\n               <jats:p>3. We have therefore developed a simple, rapid and direct microfiltration assay for the glucose-6-phosphate translocase and the phosphate\/pyrophosphate translocase.<\/jats:p>\n               <jats:p>4. We have demonstrated that the microfiltration assay can be used to directly diagnose type 1b and type 1c glycogen-storage disease in microsomes isolated from hepatic needle-biopsy samples.<\/jats:p>","DOI":"10.1042\/cs0760573","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:27:12Z","timestamp":1438946832000},"page":"573-579","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["A direct method for the diagnosis of human hepatic type 1b and type 1c glycogen-storage disease"],"prefix":"10.1042","volume":"76","author":[{"given":"Ian D.","family":"Waddell","sequence":"first","affiliation":[{"name":"Department of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Hume","sequence":"additional","affiliation":[{"name":"Department of Child Life and Health, University of Edinburgh, Edinburgh, Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Burchell","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/76\/6\/573\/508164\/cs0760573.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/76\/6\/573\/508164\/cs0760573.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:27:37Z","timestamp":1638397657000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/76\/6\/573\/74560\/A-direct-method-for-the-diagnosis-of-human-hepatic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1989,6,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0760573","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,6,1]]}}}