{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:35:25Z","timestamp":1789972525785,"version":"4.0.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,1,1]]},"abstract":"<jats:p>1. 11\u03b2-Hydroxysteroid dehydrogenase is an enzyme complex consisting of 11\u03b2-dehydrogenase and 11-oxoreductase responsible for the interconversion of cortisol to cortisone in man. Inhibition of 11\u03b2-dehydrogenase (e.g. after liquorice ingestion) results in cortisol acting as a potent mineralocorticoid. We have evaluated the effect of the synthetic liquorice derivative, carbenoxolone, on this enzyme complex.<\/jats:p>\n               <jats:p>2. Carbenoxolone given to six volunteers in metabolic balance produced sodium retention with suppression of the renin-angiotensin-aldosterone system. Plasma potassium fell, although there was no kaliuresis. This was associated with inhibition of 11\u03b2-dehydrogenase (as measured by a rise in the plasma half-life of [11\u03b1-3H]-cortisol). Unlike liquorice, however, carbenoxolone also inhibited 11-oxoreductase (as measured by the generation of cortisol after oral cortisone acetate).<\/jats:p>\n               <jats:p>3. The mineralocorticoid activity of carbenoxolone, like liquorice, is mediated via cortisol by inhibition of 11\u03b2-dehydrogenase. Carbenoxolone, however, also inhibits 11-oxoreductase activity and this may relate to its effect on renal potassium excretion.<\/jats:p>","DOI":"10.1042\/cs0780049","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:29:28Z","timestamp":1438946968000},"page":"49-54","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":148,"title":["Mineralocorticoid activity of carbenoxolone: contrasting effects of carbenoxolone and liquorice on 11<i>\u03b2<\/i>-hydroxysteroid dehydrogenase activity in man"],"prefix":"10.1042","volume":"78","author":[{"given":"P. M.","family":"Stewart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Wallace","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Glasgow Royal Infirmary, Glasgow, Scotland, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Atherden","sequence":"additional","affiliation":[{"name":"Department of Medicine, Western General Hospital, Edinburgh, Scotland, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. H.","family":"Shearing","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Western General Hospital, Edinburgh, Scotland, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. R. W.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Medicine, Western General Hospital, Edinburgh, Scotland, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/78\/1\/49\/461712\/cs0780049.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/78\/1\/49\/461712\/cs0780049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:33:12Z","timestamp":1638397992000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/78\/1\/49\/75106\/Mineralocorticoid-activity-of-carbenoxolone"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0780049","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1,1]]}}}