{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:52:13Z","timestamp":1761519133372},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,2,1]]},"abstract":"<jats:p>1. To study potassium transport in hypokalaemic periodic paralysis in a model of striated muscle cells, we measured specific [3H]ouabain binding (the number of sodium-potassium pumps), sodium-potassium-pump-mediated (ouabain-sensitive) 86Rb+ influx and sodium-potassium-pump-independent (ouabain-resistant) 86Rb+ influx in lymphocytes in vitro.<\/jats:p>\n               <jats:p>2. The subjects comprised euthyroid and thyrotoxic men with hypokalaemic periodic paralysis between attacks, men with uncomplicated thyrotoxicosis, and healthy men matched for age and weight.<\/jats:p>\n               <jats:p>3. Thyrotoxic patients, both with and without periodic paralysis, had significantly more lymphocyte sodium-potassium pumps than normal, and a significantly greater sodium-potassium-pump-mediated 86Rb+ influx. Antithyroid treatment corrected this defect in patients with thyrotoxic periodic paralysis. Euthyroid patients with cryptogenic periodic paralysis had significantly increased sodium-potassium-pump-mediated 86Rb+ influx, but a normal number of sodium-potassium pumps.<\/jats:p>\n               <jats:p>4. Only untreated thyrotoxic and euthyroid patients with periodic paralysis showed a significant increase in sodium-potassium-pump-independent 86Rb+ influx (5.2 \u00b1 2.8 and 4.5 \u00b1 1.8 respectively, vs control 2.8 \u00b1 1.0 pmol h\u22121 10\u22126 cells; mean \u00b1 sd; P &amp;lt; 0.001, P &amp;lt; 0.005).<\/jats:p>\n               <jats:p>5. We conclude that thyrotoxicosis increases the number and activity of sodium-potassium pumps and facilitates, but is probably not necessary for, periodic paralysis. Hypokalaemic periodic paralysis is associated with an increase in sodium-potassium-pump-independent potassium influx.<\/jats:p>","DOI":"10.1042\/cs0780199","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:29:28Z","timestamp":1438946968000},"page":"199-206","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Cation transport across lymphocyte plasma membranes in euthyroid and thyrotoxic men with and without hypokalaemic periodic paralysis"],"prefix":"10.1042","volume":"78","author":[{"given":"Vernon M. S.","family":"Oh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Therapeutics, National University Hospital, Singapore, Republic of Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Hwa","family":"Yeo","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Therapeutics, National University Hospital, Singapore, Republic of Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kok-Onn","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Department of Medicine, National University Hospital, Singapore, Republic of Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/78\/2\/199\/461968\/cs0780199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/78\/2\/199\/461968\/cs0780199.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:33:52Z","timestamp":1638398032000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/78\/2\/199\/75156\/Cation-transport-across-lymphocyte-plasma"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,2,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0780199","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,2,1]]}}}