{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:23:25Z","timestamp":1769840605437,"version":"3.49.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,4,1]]},"abstract":"<jats:p>1. We have investigated the frequencies of the major histocompatibility complex class II alleles by restriction fragment length polymorphism analysis, using DR, DQ and DP complementary DNA probes, in 40 Caucasoid steroid-sensitive nephrotic children.<\/jats:p>\n               <jats:p>2. A significant association with HLA-DR7 was demonstrated (P = 2 \u00d7 10\u22125; aetiological fraction 0.6). The DQB1 gene of HLA-DQw2 was present in 83% of our patients (P = 2 \u00d7 10\u22124; aetiological fraction 0.7). We present evidence that it contributes a second susceptibility allele.<\/jats:p>\n               <jats:p>3. A weak association between the uncommon HLA-DP-Cp63 allele and the disease was also observed.<\/jats:p>\n               <jats:p>4. Our data suggest that the immune events in steroid-sensitive nephrotic syndrome are defined by a particular immunogenetic background involving the \u03b2-chain genes of HLA-DR7 and HLA-DQw2.<\/jats:p>","DOI":"10.1042\/cs0780391","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:29:28Z","timestamp":1438946968000},"page":"391-397","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Genes encoding the <i>\u03b2<\/i>-chains of HLA-DR7 and HLA-DQw2 define major susceptibility determinants for idiopathic nephrotic syndrome"],"prefix":"10.1042","volume":"78","author":[{"given":"A. Godfrey B.","family":"Clark","sequence":"first","affiliation":[{"name":"Evelina Children's Department, Guy's Campus, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Molecular Immunogenetics Laboratory, Guy's Campus, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry A. F.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Molecular Immunogenetics Laboratory, Guy's Campus, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cyril","family":"Chantler","sequence":"additional","affiliation":[{"name":"Evelina Children's Department, Guy's Campus, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Gwyn","family":"Williams","sequence":"additional","affiliation":[{"name":"Renal Unit, United Medical and Dental Schools of St Thomas's and Guy's Hospitals, Guy's Campus, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth I.","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/78\/4\/391\/461993\/cs0780391.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/78\/4\/391\/461993\/cs0780391.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:31:39Z","timestamp":1638397899000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/78\/4\/391\/74988\/Genes-encoding-the-chains-of-HLA-DR7-and-HLA-DQw2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0780391","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,4,1]]}}}