{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:01:56Z","timestamp":1772992916104,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,11,1]]},"abstract":"<jats:p>1. Choline acetyltransferase activity and [3H]quinuclidinyl benzylate-binding sites were detected in the pineal gland of normotensive Wistar\u2014Kyoto rats and of spontaneously hypertensive rats.<\/jats:p>\n               <jats:p>2. In vitro, muscarinic activation by pilocarpine increased the pineal metabolic production of hydroxyindole derivatives up to 5-hydroxytryptamine and produced a less marked stimulation of melatonin biosynthesis.<\/jats:p>\n               <jats:p>3. Electrical field stimulation of pineal gland slices caused similar metabolic effects.<\/jats:p>\n               <jats:p>4. Muscarinic blockade with atropine inhibited the effects on hydroxyindole metabolism.<\/jats:p>\n               <jats:p>5. [3H]Quinuclidinyl benzylate-binding sites, indicative of muscarinic receptors, were more numerous, and basal 5-hydroxytryptamine and melatonin levels were higher, in the pineal gland of spontaneously hypertensive rats compared with Wistar\u2014Kyoto rats.<\/jats:p>\n               <jats:p>6. The atropine-sensitive metabolic effects of pilocarpine and electrical field stimulation on the pineal gland were increased in spontaneously hypertensive rats compared with Wistar-Kyoto rats.<\/jats:p>","DOI":"10.1042\/cs0790437","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:30:05Z","timestamp":1438947005000},"page":"437-442","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pineal Hyperactivity in Spontaneously Hypertensive Rats: Muscarinic Regulation of Indole Metabolism"],"prefix":"10.1042","volume":"79","author":[{"given":"Liliana M. E.","family":"Finocchiaro","sequence":"first","affiliation":[{"name":"Laboratorio de Sustancias Vasoactivas, Instituto de Investigaciones M\u00e9dicas, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Scheucher","sequence":"additional","affiliation":[{"name":"Laboratorio de Sustancias Vasoactivas, Instituto de Investigaciones M\u00e9dicas, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azucena L.","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Laboratorio de Sustancias Vasoactivas, Instituto de Investigaciones M\u00e9dicas, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Finkielman","sequence":"additional","affiliation":[{"name":"Laboratorio de Sustancias Vasoactivas, Instituto de Investigaciones M\u00e9dicas, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor E.","family":"Nahmod","sequence":"additional","affiliation":[{"name":"Laboratorio de Sustancias Vasoactivas, Instituto de Investigaciones M\u00e9dicas, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos J.","family":"Pirola","sequence":"additional","affiliation":[{"name":"Laboratorio de Sustancias Vasoactivas, Instituto de Investigaciones M\u00e9dicas, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/79\/5\/437\/462452\/cs0790437.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/79\/5\/437\/462452\/cs0790437.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:35:14Z","timestamp":1638398114000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/79\/5\/437\/75244\/Pineal-Hyperactivity-in-Spontaneously-Hypertensive"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1990,11,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0790437","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,11,1]]}}}