{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T01:55:01Z","timestamp":1698285301949},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,1,1]]},"abstract":"<jats:p>1. Reserpine (5 mg\/kg intraperitoneally) produced gastric mucosal vasoconstriction and injury in all rats within 6 h (injury score 38.8 \u00b1 2.1 mm2, mean \u00b1 SEM). Coeliac ganglionectomy or the \u03b2-adrenoceptor-blocking drug propranolol (5\u201315 mg\/kg) did not influence these effects of reserpine, but vagotomy protected the rats against them. The \u03b1-adrenoceptor-blocking drugs phenoxybenzamine and phentolamine at 5 mg\/kg were protective against injury. However, a 10 mg\/kg dose of either blocker was more effective (2.2 \u00b1 0.5 mm2 and 3 \u00b1 0.8 mm2, respectively, versus 38.8 \u00b1 2.1 mm2, mean \u00b1 SEM, P &amp;lt;0.01) and a dose of 15 mg\/kg afforded complete protection.<\/jats:p>\n               <jats:p>2. Methysergide, a 5-hydroxytryptamine receptor antagonist, produced a dose-dependent increase in the reserpine-induced injury; a significant (P &amp;lt;0.05) increase was noted with 15 and 20 mg\/kg (47.5 \u00b1 2.9 mm2 and 49.4 \u00b1 2.2 mm2, respectively, versus 38.8 \u00b1 2.1 mm2, mean \u00b1 SEM).<\/jats:p>\n               <jats:p>3. The results suggest that, in the rat, reserpine causes vagal \u03b1-adrenoceptor stimulation producing gastric mucosal vasoconstriction and injury. 5-Hydroxytryptamine is not implicated in the mechanism of this injury and affords protection against it.<\/jats:p>","DOI":"10.1042\/cs0800059","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:31:20Z","timestamp":1438947080000},"page":"59-64","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mechanism of reserpine-induced acute gastric mucosal injury in the rat: role of endogenous 5-hydroxytryptamine"],"prefix":"10.1042","volume":"80","author":[{"given":"Aws S.","family":"Saum","sequence":"first","affiliation":[{"name":"University Department of Surgery, Royal Infirmary, Glasgow, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/80\/1\/59\/462526\/cs0800059.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/80\/1\/59\/462526\/cs0800059.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:32:49Z","timestamp":1638397969000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/80\/1\/59\/75077\/Mechanism-of-reserpine-induced-acute-gastric"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0800059","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1,1]]}}}