{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:58:41Z","timestamp":1778842721280,"version":"3.51.4"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,3,1]]},"abstract":"<jats:p>1. A compound identified as orotidine has been found in the erythrocytes of all subjects on allopurinol.<\/jats:p>\n               <jats:p>2. The erythrocyte orotidine concentrations were much higher in patients with renal failure or with the Lesch-Nyhan syndrome.<\/jats:p>\n               <jats:p>3. In addition, increased amounts of oxypurinol-7-riboside were excreted in the urine by both of these groups compared with control subjects or with patients with normal renal function on allopurinol.<\/jats:p>\n               <jats:p>4. A good correlation was found between urinary oxypurinol-7-riboside excretion and erythrocyte orotidine concentrations.<\/jats:p>\n               <jats:p>5. Increased erythrocyte levels of the pyrimidine-sugar UDP-glucose were also found in patients with the highest orotidine levels.<\/jats:p>\n               <jats:p>6. The combined results suggest a derangement of pyrimidine nucleotide metabolism during allopurinol therapy. We propose that erythrocyte orotidine formation results primarily from inhibition of orotidine-5\u2032-mono-phosphate decarboxylase by oxypurinol-7-ribotide.<\/jats:p>","DOI":"10.1042\/cs0800191","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:31:20Z","timestamp":1438947080000},"page":"191-197","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Orotidine Accumulation in Human Erythrocytes during Allopurinol Therapy: Association with High Urinary Oxypurinol-7-Riboside Concentrations in Renal Failure and in the Lesch-Nyhan Syndrome"],"prefix":"10.1042","volume":"80","author":[{"given":"H. A.","family":"Simmonds","sequence":"first","affiliation":[{"name":"Purine Research Laboratory and Renal Unit, Clinical Science Laboratories, UMDS, Guy's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Reiter","sequence":"additional","affiliation":[{"name":"Purine Research Laboratory and Renal Unit, Clinical Science Laboratories, UMDS, Guy's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. M.","family":"Davies","sequence":"additional","affiliation":[{"name":"Purine Research Laboratory and Renal Unit, Clinical Science Laboratories, UMDS, Guy's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Purine Research Laboratory and Renal Unit, Clinical Science Laboratories, UMDS, Guy's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/80\/3\/191\/462800\/cs0800191.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/80\/3\/191\/462800\/cs0800191.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:35:03Z","timestamp":1638398103000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/80\/3\/191\/75235\/Orotidine-Accumulation-in-Human-Erythrocytes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0800191","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,3,1]]}}}