{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:45:33Z","timestamp":1771461933175,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,3,1]]},"abstract":"<jats:p>1. Atrial natriuretic factor is metabolized by neutral endopeptidase (atriopeptidase; EC 3.4.24.11) in vitro. Inhibitors of this enzyme have been reported to prolong the half-life of atrial natriuretic factor in vivo and to potentiate the renal and haemodynamic effects of exogenous atrial natriuretic factor.<\/jats:p>\n               <jats:p>2. (\u00b1)-Candoxatrilat, a selective neutral endopeptidase inhibitor, potentiated the natriuretic and diuretic response to volume loading in anaesthetized rats. Part of the response to volume loading and the potentiation by (\u00b1)-candoxatrilat was prevented by a polyclonal atrial natriuretic factor antiserum. The diuretic and natriuretic responses evoked by hydrochlorothiazide were not altered by the antiserum.<\/jats:p>\n               <jats:p>3. (\u00b1)-Candoxatrilat reduced systolic blood pressure of one-kidney deoxycorticosterone acetate-salt hypertensive rats for over 5 h. This response was abolished by pretreatment with atrial natriuretic factor antiserum.<\/jats:p>\n               <jats:p>4. These data demonstrate that the neutral endopeptidase inhibitor (\u00b1)-candoxatrilat has natriuretic\/diuretic and antihypertensive effects in rodents, and that these effects are mediated via endogenous atrial natriuretic factor.<\/jats:p>","DOI":"10.1042\/cs0800265","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:31:20Z","timestamp":1438947080000},"page":"265-269","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Inhibition of Neutral Endopeptidase (EC 3.4.24.11) Leads to An Atrial Natriuretic Factor-Mediated Natriuretic, Diuretic and Antihypertensive Response in Rodents"],"prefix":"10.1042","volume":"80","author":[{"given":"N. B.","family":"Shepperson","sequence":"first","affiliation":[{"name":"Pfizer Central Research, Sandwich, Kent, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. L.","family":"Barclay","sequence":"additional","affiliation":[{"name":"Pfizer Central Research, Sandwich, Kent, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Bennett","sequence":"additional","affiliation":[{"name":"Pfizer Central Research, Sandwich, Kent, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. M. R.","family":"Samuels","sequence":"additional","affiliation":[{"name":"Pfizer Central Research, Sandwich, Kent, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/80\/3\/265\/462808\/cs0800265.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/80\/3\/265\/462808\/cs0800265.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:35:11Z","timestamp":1638398111000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/80\/3\/265\/75242\/Inhibition-of-Neutral-Endopeptidase-EC-3-4-24-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1991,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0800265","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,3,1]]}}}