{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T17:52:31Z","timestamp":1693504351312},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,7,1]]},"abstract":"<jats:p>1. In patients with cystic fibrosis, abnormalities in plasma cholecystokinin level and gall-bladder emptying may contribute to the development of maldigestion and gall-stones.<\/jats:p>\n               <jats:p>2. Therefore, we have measured plasma cholecystokinin levels and gall-bladder volumes before and after ingestion of a standard breakfast in eight adult patients with cystic fibrosis and in eight normal control subjects.<\/jats:p>\n               <jats:p>3. In the patients with cystic fibrosis basal (2.8 \u00b1 0.4 pmol\/l; P &amp;lt; 0.05, t-test) and maximum post-prandial (5.7 \u00b1 0.5 pmol\/l; P &amp;lt; 0.05, t-test) plasma cholecystokinin levels were significantly higher than those in the control subjects (1.9 \u00b1 0.1 pmol\/l, and 4.5 \u00b1 0.2 pmol\/l, respectively). On the other hand, integrated plasma cholecystokinin secretion in response to the meal was similar (t-test, P = 0.4 versus control subjects). The increased plasma cholecystokinin levels in the patients with cystic fibrosis were accompanied by reduced gallbladder volumes in both the basal (7.8 \u00b1 2.1 cm3 versus 20.9 \u00b1 2.3 cm3 in control subjects; P &amp;lt; 0.005, t-test) and the post-prandial state (2.2 \u00b1 1.0 cm3 versus 4.8 \u00b1 0.8 cm3 in control subjects; P = 0.06, t-test). Gall-bladder emptying in the patients with cystic fibrosis was well preserved (70 \u00b1 7% versus 78 \u00b1 9% in control subjects; P = 0.4, t-test).<\/jats:p>\n               <jats:p>4. In comparison with normal control subjects, patients with cystic fibrosis have an increased basal plasma cholecystokinin level and a reduced gall-bladder volume, whereas post-prandial gall-bladder emptying and plasma cholecystokinin secretion are not significantly different. In cystic fibrosis, neither impaired cholecystokinin release nor impaired gall-bladder emptying appear to play a role in the pathogenesis of either gall-stones or maldigestion.<\/jats:p>","DOI":"10.1042\/cs0810085","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:33:17Z","timestamp":1438947197000},"page":"85-89","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Increased plasma cholecystokinin levels and small gall bladders in adult patients with cystic fibrosis"],"prefix":"10.1042","volume":"81","author":[{"given":"E. H. J.","family":"van Haren","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. P. M.","family":"Hopman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. B. M. J.","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital Leiden, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Rosenbusch","sequence":"additional","affiliation":[{"name":"Department of Radiology, Division of Pulmonary Diseases, University Hospital Nijmegen, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. B. H. W.","family":"Lamers","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital Leiden, Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. L. A.","family":"van Herwaarden","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonary Diseases, University Hospital Nijmegen, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/81\/1\/85\/463042\/cs0810085.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/81\/1\/85\/463042\/cs0810085.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:34:17Z","timestamp":1638398057000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/81\/1\/85\/75179\/Increased-plasma-cholecystokinin-levels-and-small"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0810085","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7,1]]}}}