{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:43:47Z","timestamp":1772894627203,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s25","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,10,1]]},"abstract":"<jats:p>1. Expression of intercellular adhesion molecule-1 was investigated in five normal kidneys and 47 renal biopsies with the use of monoclonal antibody 7F7 and immunoperoxidase staining.<\/jats:p>\n               <jats:p>2. In the normal kidney, intercellular adhesion molecule-1 was expressed on endothelial cells of glomerular and peritubular capillaries, on Bowman's capsule, on some interstitial cells and weakly in the mesangium.<\/jats:p>\n               <jats:p>3. Increased glomerular staining was detected in early cases of rapidly progressing glomerulonephritis (5\/8) and in some cases of non-IgA mesangioproliferative glomerulonephritis (5\/9), IgA nephropathy (3\/5), Henoch-Schoenlein purpura (2\/2), lupus nephritis (5\/6) and focal segmental glomerulosclerosis (1\/3). A decrease in intercellular adhesion molecule-1 expression was noted in advanced rapidly progressive glomerulonephritis (3\/8), two cases of membraneous nephropathy, one severe mesangioproliferative glomerulonephritis biopsy, the two membranoproliferative glomerulonephritis biopsies and in sclerotic loops in focal segmental glomerulosclerosis.<\/jats:p>\n               <jats:p>4. Expression de novo on tubular epithelial cells occurred in rapidly progressive glomerulonephritis, in membranoproliferative glomerulonephritis, and to a lesser extent in some cases of membranous nephropathy, minimal change disease, IgA nephropathy, focal segmental glomerulosclerosis, a severe case of mesangioproliferative glomerulonephritis and in the mixed essential cryoglobulinaemia case. In 63% of positive tubuli, intraluminal cells which expressed CD18, the common \u03b2-chain of leucocyte-function-associated antigen-1, Mac-1 and p150,95, were present.<\/jats:p>\n               <jats:p>5. Intercellular adhesion molecule-1 was also found on the majority (59%) of infiltrating mononuclear cells in all forms of glomerulonephritis.<\/jats:p>","DOI":"10.1042\/cs0810477","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:33:17Z","timestamp":1438947197000},"page":"477-481","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Renal expression of intercellular adhesion molecule-1 in different forms of glomerulonephritis"],"prefix":"10.1042","volume":"81","author":[{"given":"K.","family":"Lhotta","sequence":"first","affiliation":[{"name":"Clinical Nephrology Division, Department of Internal Medicine, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. P.","family":"Neumayer","sequence":"additional","affiliation":[{"name":"Institute of Hygiene, University Hospital Innsbruck, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Joannidis","sequence":"additional","affiliation":[{"name":"Clinical Nephrology Division, Department of Internal Medicine, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Geissler","sequence":"additional","affiliation":[{"name":"Clinical Nephrology Division, Department of Internal Medicine, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"K\u00f6Nig","sequence":"additional","affiliation":[{"name":"Clinical Nephrology Division, Department of Internal Medicine, Innsbruck, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/81\/s25\/477\/744236\/cs0810477.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/81\/s25\/477\/744236\/cs0810477.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T23:55:22Z","timestamp":1638402922000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/81\/s25\/477\/96850\/Renal-expression-of-intercellular-adhesion"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,10,1]]},"references-count":0,"journal-issue":{"issue":"s25","published-print":{"date-parts":[[1991,10,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0810477","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1991,10,1]]}}}