{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T17:37:15Z","timestamp":1770831435944,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,11,1]]},"abstract":"<jats:p>1. l-Arginine is the physiological precursor for the formation of endothelium-derived nitric oxide. The synthesis of nitric oxide is stereospecific: d-arginine is not a substrate for nitric oxide synthase. It is possible that the provision of excess l-arginine substrate might increase the vascular synthesis of nitric oxide. We have examined this possibility by studying the effects of local infusion of l-and d-arginine in the forearm resistance bed and the superficial dorsal hand veins of healthy subjects.<\/jats:p>\n               <jats:p>2. Drugs were either infused locally into a vein on the back of the hand and then the vein diameter was measured using a linear displacement technique, or into the brachial artery and then the forearm blood flow was measured by venous occlusion plethysmography.<\/jats:p>\n               <jats:p>3. In the superficial hand veins, l- and d-arginine free base and l- and d-arginine hydrochloride (all four preparations at a dose of 5 \u03bcmol\/min) all caused a significant increase in venous diameter. The responses of the l-and d-enantiomers did not differ significantly from one another.<\/jats:p>\n               <jats:p>4. In the forearm resistance bed, l- and d-arginine free base and l-arginine hydrochloride were without effect at doses of 10 and 40 \u03bcmol\/min. However, at doses of 160 \u03bcmol\/min all three preparations of arginine caused a significant increase in forearm blood flow compared with control values. The responses to the three preparations of arginine did not differ significantly from one another.<\/jats:p>\n               <jats:p>5. These results show that arginine in high dose is a vasodilator in both human resistance vessels and superficial veins in vivo. The response to arginine was not stereospecific: both the l- and d-enantiomers had the same effect. The dilator effect of high-dose arginine showed neither arterio-nor veno-selectivity.<\/jats:p>\n               <jats:p>6. This suggests that the hypotensive effect of systemic infusions of l-arginine in man is mediated by peripheral vasodilatation. It is not possible to ascribe the actions of arginine supplementation in this study to activation of the l-arginine\/nitric oxide pathway through the provision of excess substrate.<\/jats:p>","DOI":"10.1042\/cs0810695","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:33:17Z","timestamp":1438947197000},"page":"695-700","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Dilator actions of arginine in human peripheral vasculature"],"prefix":"10.1042","volume":"81","author":[{"given":"Alison","family":"Calver","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joe","family":"Collier","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Vallance","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Clinical Pharmacology, St George's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/81\/5\/695\/463230\/cs0810695.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/81\/5\/695\/463230\/cs0810695.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:37:21Z","timestamp":1638398241000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/81\/5\/695\/75454\/Dilator-actions-of-arginine-in-human-peripheral"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1991,11,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0810695","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,11,1]]}}}