{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:29:25Z","timestamp":1789032565850,"version":"build-2803163510"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,2,1]]},"abstract":"1. We investigated the effects of starting amino acid administration on post-natal day 2 on protein turnover and nitrogen balance in appropriate-for-gestational-age, very-low-birth-weight infants. Eighteen infants were divided into two groups. Group A received from day 2 onwards an amino acid solution, whereas group B started on this solution after day 4. Both groups were exclusively parenterally fed, 200 kJ day\u22121 kg\u22121 on post-natal days 3 and 4. Group A (birth weight 1.5 \u00b1 0.3 kg) received 4.6 g of glucose, 1.9 g of fat and 2.3 g of amino acids day\u22121 kg\u22121 body weight. Group B (birth weight 1.4 \u00b1 0.2 kg) received 7.0 g of glucose and 1.9 g of fat day\u22121 kg\u22121 body weight.<\/jats:p>\n 2. At post-natal day 3, a primed constant infusion of 3 mg of [15N]glycine day\u22121 kg\u22121 was given. Protein flux, protein synthesis and protein breakdown were calculated from the 15N enrichment in urinary ammonia. In five out of nine infants in group B no plateau of 15N enrichment in urinary urea could be detected, whereas in group A two out of nine infants did not reach a plateau. For this reason we did not use the end product urea for our calculations.<\/jats:p>\n 3. The administration of the amino acids resulted in a higher protein flux (6.9 \u00b1 1.5 g day\u22121 kg\u22121 versus 5.2 \u00b1 0.9 g day\u22121 kg\u22121) and a higher protein synthesis rate (6.0 \u00b1 1.4 g day\u22121 kg\u22121 versus 4.6 \u00b1 0.8 g day\u22121 kg\u22121) in group A. There was no statistically significant difference in protein breakdown. The administration of amino acids reversed a negative protein balance (\u22120.6 \u00b1 0.2 g day\u22121 kg\u22121) into a positive one (1.4 \u00b1 0.2 g day\u22121 kg\u22121. No adverse effects of the amino acid infusion were seen.<\/jats:p>\n 4. We conclude that the early introduction of amino acids has, even at this relatively low energy intake of 200 kJ day\u22121 kg\u22121, a positive effect on protein balance by increasing protein synthesis.<\/jats:p>","DOI":"10.1042\/cs0820199","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:33:36Z","timestamp":1438947216000},"page":"199-203","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Effects of early amino acid administration during total parenteral nutrition on protein metabolism in pre-term infants"],"prefix":"10.1042","volume":"82","author":[{"given":"R. A.","family":"van Lingen","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Subdivision of Neonatology, Erasmus University and University Hospital Rotterdam\/Sophia Children's Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. B.","family":"van Goudoever","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Subdivision of Neonatology, Erasmus University and University Hospital Rotterdam\/Sophia Children's Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. H. T.","family":"Luijendijk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Subdivision of Neonatology, Erasmus University and University Hospital Rotterdam\/Sophia Children's Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L. D.","family":"Wattimena","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Erasmus University and University Hospital Rotterdam\/Sophia Children's Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J. J.","family":"Sauer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Subdivision of Neonatology, Erasmus University and University Hospital Rotterdam\/Sophia Children's Hospital, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/82\/2\/199\/463365\/cs0820199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/82\/2\/199\/463365\/cs0820199.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:38:46Z","timestamp":1638398326000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/82\/2\/199\/75601\/Effects-of-early-amino-acid-administration-during"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,2,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0820199","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,2,1]]}}}