{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T08:20:38Z","timestamp":1782894038692,"version":"3.54.5"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,5,1]]},"abstract":"<jats:p>1. The kinin antagonist des-Arg9\u2212[Leu8]bradykinin, injected into the lateral ventricle, caused a long-lasting, dose-dependent reduction in arterial blood pressure and heart rate in spontaneously hypertensive rats but not in normotensive Wistar-Kyoto rats; the antagonist also blocked the pressor response to ventricularly infused bradykinin in both strains.<\/jats:p>\n               <jats:p>2. Bradykinin content was increased in the hypothalamus and septum and decreased in the dorsal medulla of spontaneously hypertensive rats when compared with those of normotensive Wistar-Kyoto rats, whereas similar bradykinin contents were observed in the pineal gland, hypophysis and rostroventrolateral medulla of both rat strains.<\/jats:p>\n               <jats:p>3. Increased concentrations of bradykinin and its precursor kininogen were found in the cerebrospinal fluid of spontaneously hypertensive rats.<\/jats:p>\n               <jats:p>4. Bradykinin receptor numbers, measured as the binding of [125I-Tyr1]bradykinin to nervous tissue, were found to be increased in the dorsal medulla and hypophysis, and to be decreased in the pineal gland, of spontaneously hypertensive rats.<\/jats:p>\n               <jats:p>5. Therefore, the central kinin system may participate, by both pre- and post-synaptic mechanisms, in the maintenance of hypertension in spontaneously hypertensive rats.<\/jats:p>","DOI":"10.1042\/cs0820513","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:33:36Z","timestamp":1438947216000},"page":"513-519","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Central bradykininergic system in normotensive and hypertensive rats"],"prefix":"10.1042","volume":"82","author":[{"given":"Azucena L.","family":"Alvarez","sequence":"first","affiliation":[{"name":"Laboratorio de Sustancias Vasoactives, Instituto de Investigaciones Medicas \u2018A. Lanari\u2019, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Delorenzi","sequence":"additional","affiliation":[{"name":"Laboratorio de Sustancias Vasoactives, Instituto de Investigaciones Medicas \u2018A. Lanari\u2019, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Santajuliana","sequence":"additional","affiliation":[{"name":"Laboratorio de Sustancias Vasoactives, Instituto de Investigaciones Medicas \u2018A. Lanari\u2019, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Finkielman","sequence":"additional","affiliation":[{"name":"Laboratorio de Sustancias Vasoactives, Instituto de Investigaciones Medicas \u2018A. Lanari\u2019, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor E.","family":"Nahmod","sequence":"additional","affiliation":[{"name":"Laboratorio de Sustancias Vasoactives, Instituto de Investigaciones Medicas \u2018A. Lanari\u2019, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos J.","family":"Pirola","sequence":"additional","affiliation":[{"name":"Laboratorio de Sustancias Vasoactives, Instituto de Investigaciones Medicas \u2018A. Lanari\u2019, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/82\/5\/513\/463429\/cs0820513.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/82\/5\/513\/463429\/cs0820513.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:39:29Z","timestamp":1638398369000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/82\/5\/513\/75699\/Central-bradykininergic-system-in-normotensive-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0820513","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,5,1]]}}}