{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T02:19:01Z","timestamp":1694917141225},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,12,1]]},"abstract":"<jats:p>1. The existence of specific glucose-6-phosphatase activity in human intestinal mucosa has been somewhat controversial.<\/jats:p>\n               <jats:p>2. We have demonstrated the presence of low levels of specific glucose-6-phosphatase activity in normal human adult intestinal mucosa. Activity was found in oesophagus, stomach, duodenum and colon.<\/jats:p>\n               <jats:p>3. Immunoblot analysis using antibodies monospecific for the 36.5 kDa liver glucose-6-phosphatase catalytic subunit demonstrated that intestinal mucosa contains low levels of the glucose-6-phosphatase enzyme protein.<\/jats:p>\n               <jats:p>4. The low levels of activity together with problems of proteolysis make human intestinal biopsies unsuitable for use in the diagnosis of type 1 glycogen-storage disease.<\/jats:p>","DOI":"10.1042\/cs0830683","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:34:06Z","timestamp":1438947246000},"page":"683-687","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Glucose-6-phosphatase in normal adult human intestinal mucosa"],"prefix":"10.1042","volume":"83","author":[{"given":"John","family":"Pears","sequence":"first","affiliation":[{"name":"Deapartment of Medicine, Ninewells Hospital and Medical School, Dundee, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland T.","family":"Jung","sequence":"additional","affiliation":[{"name":"Deapartment of Medicine, Ninewells Hospital and Medical School, Dundee, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Jankowski","sequence":"additional","affiliation":[{"name":"Deapartment of Medicine, Ninewells Hospital and Medical School, Dundee, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian D.","family":"Waddell","sequence":"additional","affiliation":[{"name":"Centre for Research into Human Development, Department of Obstetrics and Gynaecology and Department of Child Health, Ninewells Hospital and Medical School, Dundee, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Burchell","sequence":"additional","affiliation":[{"name":"Centre for Research into Human Development, Department of Obstetrics and Gynaecology and Department of Child Health, Ninewells Hospital and Medical School, Dundee, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/83\/6\/683\/463833\/cs0830683.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/83\/6\/683\/463833\/cs0830683.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:40:25Z","timestamp":1638398425000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/83\/6\/683\/75784\/Glucose-6-phosphatase-in-normal-adult-human"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1992,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0830683","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,12,1]]}}}