{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T05:36:51Z","timestamp":1770442611542,"version":"3.49.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,3,1]]},"abstract":"<jats:p>1. The present study was undertaken to test whether insulin acts as a pressor agent and causes hypertension in rats.<\/jats:p>\n               <jats:p>2. Insulin at doses of 10 or 100 units day\u22121 kg\u22121 was administered daily by subcutaneous injection to normal rats for 6 weeks. As it has been suggested that sodium retention plays a major role in the putative hypertensive activity of this hormone, insulin was also administered to saline- (1% NaCl) drinking rats according to the same protocol. Water- and saline-drinking rats served as controls.<\/jats:p>\n               <jats:p>3. After 6 weeks of insulin treatment, the mean arterial blood pressure did not increase in any of the insulin-treated or the insulin-salt-treated groups. However, in both insulin-salt-treated groups, absolute and relative ventricular and renal hypertrophy with increased ventricular water content as well as increased urine output with reduced osmolality were observed.<\/jats:p>\n               <jats:p>4. All insulin-treated groups showed increased plasma levels of glucose, insulin and antidiuretic hormone when compared with their respective controls.<\/jats:p>\n               <jats:p>5. These results demonstrate that chronic insulin treatment did not increase blood pressure in rats, even when drinking water was supplemented with NaCl, and suggest that a polyuria-polydipsia syndrome was present in both insulin-salt-treated groups. Moreover, increased plasma levels of antidiuretic hormone were observed in all insulin-treated groups.<\/jats:p>","DOI":"10.1042\/cs0840281","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:34:58Z","timestamp":1438947298000},"page":"281-286","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Chronic insulin treatment in rats: Evidence against a role for insulin as a pressor agent"],"prefix":"10.1042","volume":"84","author":[{"given":"F\u00e9lix","family":"Vargas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Mario","family":"Sabio","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Angel","family":"Castillo","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"De Dios Luna","sequence":"additional","affiliation":[{"name":"Departamento de Bioestadistica, Facultad de Medicina, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Manuel","family":"Haro","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cipriano","family":"Garc\u00eda Del R\u00edo","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/84\/3\/281\/463995\/cs0840281.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/84\/3\/281\/463995\/cs0840281.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:41:34Z","timestamp":1638398494000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/84\/3\/281\/75860\/Chronic-insulin-treatment-in-rats-Evidence-against"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0840281","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,3,1]]}}}