{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T19:59:35Z","timestamp":1698436775156},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,4,1]]},"abstract":"<jats:p>1. Glomerular charge selectivity was assessed using the ratio of the clearance of pancreatic isoamylase to the clearance of the more anionic salivary isoamylase (CPAm\/CSAm) in 30 normal subjects, 14 patients with minimal proteinuria and 23 patients with heavy proteinuria due to primary glomerulopathies. Seven patients with minimal change nephropathy were studied in relapse and remission.<\/jats:p>\n               <jats:p>2. CPAm\/CSAm exceeded 2.0 (range 2.1-6.1) in all normal subjects, indicating that the normal glomerular capillary wall possesses charge selectivity at the molecular size of amylase (molecular mass 56 kDa). 3. CPAm\/CSAm was significantly lower in patients with heavy proteinuria than in normal subjects or patients with minimal proteinuria. CPAm\/CSAm was low in patients with minimal change nephropathy in relapse and rose into the normal range with steroid-induced remission.<\/jats:p>\n               <jats:p>4. These data suggest that heavy proteinuria in primary glomerulopathies is accompanied by loss of glomerular charge selectivity. Remission of minimal change nephropathy is associated with restoration of normal charge selectivity.<\/jats:p>","DOI":"10.1042\/cs0840449","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:34:58Z","timestamp":1438947298000},"page":"449-454","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Assessment of Glomerular Charge Selectivity in Man by Differential Clearance of Isoamylases"],"prefix":"10.1042","volume":"84","author":[{"given":"J. G.","family":"Fox","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Quin","sequence":"additional","affiliation":[{"name":"Renal Unit Diabetic Unit, Royal Infirmary, Glasgow, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Stj.","family":"O'reilly","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Royal Infirmary, Glasgow, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Boulton-Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/84\/4\/449\/464142\/cs0840449.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/84\/4\/449\/464142\/cs0840449.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:43:00Z","timestamp":1638398580000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/84\/4\/449\/75971\/Assessment-of-Glomerular-Charge-Selectivity-in-Man"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0840449","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,4,1]]}}}