{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:15:31Z","timestamp":1783721731852,"version":"3.55.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,3,1]]},"abstract":"<jats:p>1. Anomalous transmembrane anion transport has been observed in erythrocytes of patients with idiopathic calcium nephrolithiasis.<\/jats:p>\n               <jats:p>2. To verify whether cation transport is also abnormal, we investigated the frusemide-sensitive Na+ efflux from Na+-loaded erythrocytes and the natriuretic response to acute intravenous frusemide administration in calcium oxalate renal stone formers.<\/jats:p>\n               <jats:p>3. Frusemide administration induced a statistically significant smaller increase in the fractional excretion of Na+ in patients than in control subjects. Abnormal kinetic properties of erythrocyte Na+-K+-2Cl\u2212 co-transport were observed in approximately 60% of stone formers. The Km for Na+ of Na+-K+-2Cl\u2212 co-transport correlated with urinary Ca2+ excretion.<\/jats:p>\n               <jats:p>4. The abnormal kinetic properties of Na+-K+-2Cl\u2212 co-transport may be relevant for stone formation, hampering renal Ca2+ reabsorption in the distal nephron and determining critical physicochemical conditions for calcium\/oxalate crystallization.<\/jats:p>","DOI":"10.1042\/cs0860239","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:35:14Z","timestamp":1438947314000},"page":"239-243","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Abnormal Erythrocyte and Renal Frusemide-Sensitive Sodium Transport in Idiopathic Calcium Nephrolithiasis"],"prefix":"10.1042","volume":"86","author":[{"given":"Bruno","family":"Baggio","sequence":"first","affiliation":[{"name":"Division of Nephrology, Institute of Internal Medicine, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Gambaro","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Institute of Internal Medicine, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Marchini","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Institute of Internal Medicine, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Vincenti","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Institute of Internal Medicine, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Ceolotto","sequence":"additional","affiliation":[{"name":"Division of Clinical Medicine, Policlinico Universitario, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achille C.","family":"Pessina","sequence":"additional","affiliation":[{"name":"Division of Clinical Medicine, Policlinico Universitario, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Semplicini","sequence":"additional","affiliation":[{"name":"Division of Clinical Medicine, Policlinico Universitario, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/86\/3\/239\/464507\/cs0860239.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/86\/3\/239\/464507\/cs0860239.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:48:11Z","timestamp":1638398891000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/86\/3\/239\/76141\/Abnormal-Erythrocyte-and-Renal-Frusemide-Sensitive"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0860239","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3,1]]}}}