{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:19:12Z","timestamp":1778275152056,"version":"3.51.4"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,3,1]]},"abstract":"1. The purpose of this study was to determine whether the 24 h urinary albumin excretory rate was increased in the third trimester of normal pregnancy or in pregnant women with hypertension who had 24 h urinary total protein excretion within the normal range.<\/jats:p>\n 2. Twenty-four hour urinary creatinine and albumin excretions were determined prospectively in 26 non-pregnant and 115 pregnant women in their third trimester (40 in normal pregnancy, 38 with mild pre-eclampsia, 20 with severe pre-eclampsia, 17 with essential hypertension) in whom urinary total protein excretion was normal. Both the urinary albumin excretion rate and the urinary albumin\/creatinine ratio were compared among the groups. The clearance of albumin relative to that of creatinine was also calculated in the hypertensive women and in 14 of the non-pregnant women and nine of the normal pregnant women.<\/jats:p>\n 3. The twenty-four hour urinary albumin excretion rate was similar in non-pregnant [8(5\u201310) mg\/day; median (interquartile range)] and normal pregnant [7(6\u201310) mg\/day] women. Women with essential hypertension [6(4\u201316) mg\/day] and mild pre-eclampsia [7(4\u201310) mg\/day] had a urinary albumin excretion rate similar to that of normal pregnant women. Women with severe pre-eclampsia had an urinary albumin excretion rate increased [13(7\u201332) mg\/day] compared with other groups (P &lt; 0.05). The clearance of albumin relative to that of creatinine was elevated significantly only in women with severe pre-eclampsia compared with normal pregnant women (0.00054 versus 0.00012; P &lt; 0.05). Blood pressures were similar among all hypertensive groups. The upper limit of the urinary albumin excretion rate was 20 mg\/day in normal pregnant women, similar to that in non-pregnant women.<\/jats:p>\n 4. Urinary albumin excretion is unchanged in the third trimester of normal pregnancy, but is increased in women with features of severe pre-eclampsia who have normal total urinary protein excretion. This is not fully explained by a reduction in glomerular filtration rate nor by different systemic blood pressures, and probably reflects enhanced glomerular capillary permeability, possibly with altered maximum renal tubular reabsorption capacity for albumin.<\/jats:p>","DOI":"10.1042\/cs0860251","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:35:14Z","timestamp":1438947314000},"page":"251-255","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Albumin Excretory Rate in Normal and Hypertensive Pregnancy"],"prefix":"10.1042","volume":"86","author":[{"given":"Mark A.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Renal Medicine, University of New South Wales, Sydney, Australia"},{"name":"Department of Medicine, University of New South Wales, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Xia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, University of New South Wales, Sydney, Australia"},{"name":"Department of Medicine, University of New South Wales, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan L.","family":"Buddle","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, University of New South Wales, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark A.","family":"Carlton","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, St George Hospital and University of New South Wales, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory M.","family":"Cario","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, St George Hospital and University of New South Wales, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivienne C.","family":"Zammit","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, University of New South Wales, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith A.","family":"Whitworth","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, University of New South Wales, Sydney, Australia"},{"name":"Department of Medicine, University of New South Wales, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/86\/3\/251\/464537\/cs0860251.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/86\/3\/251\/464537\/cs0860251.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:48:20Z","timestamp":1638398900000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/86\/3\/251\/76152\/Albumin-Excretory-Rate-in-Normal-and-Hypertensive"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0860251","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,3,1]]}}}