{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:30:31Z","timestamp":1773307831498,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,4,1]]},"abstract":"<jats:p>1. Hypovolaemic shock associated with surgical trauma has been studied in a rat liver ischaemia-reperfusion model by determination of oxidative stress, lipid peroxidation and tissue infiltration of polymorphonuclear leucocytes.<\/jats:p>\n               <jats:p>2. Liver ischaemia alone resulted in slight liver oedema and polymorphonuclear leucocyte infiltration, a slight increase in thiobarbituric acid-reacting substances (an index of lipid peroxidation) and decreases in liver reduced glutathione and total radical-trapping antioxidant parameter, indices of oxidative stress. Ischaemia plus 30 min of reperfusion further increased liver oedema, polymorphonuclear leucocyte infiltration and thiobarbituric-acid reacting substances, and further decreased liver reduced glutathione and total radical-trapping antioxidant parameter.<\/jats:p>\n               <jats:p>3. After 60 and 90 min of reperfusion, oedema (40% increase), polymorphonuclear leucocyte infiltration (40-fold increase) and thiobarbituric-acid reacting substances (20-fold increase) were maximal, and liver reduced glutathione (75\u201395% decrease) and total radical-trapping antioxidant parameter (85\u201390% decrease) were at a minimum.<\/jats:p>\n               <jats:p>4. All parameters were exacerbated by 24 h starvation. Liver reduced glutathione closely paralleled total radical-trapping antioxidant parameter, and ischaemia alone depleted both by 30% in fed rats and 50% in fasted rats.<\/jats:p>\n               <jats:p>5. Oxidative stress and lipid peroxidation were associated more with the period of reperfusion and polymorphonuclear leucocyte infiltration. Polymorphonuclear leucocyte infiltration into lung also occurred after 90 min of liver reperfusion.<\/jats:p>\n               <jats:p>6. Possible mechanisms of hepatic ischaemia-reperfusion-induced oxidative stress are discussed.<\/jats:p>","DOI":"10.1042\/cs0860453","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:35:14Z","timestamp":1438947314000},"page":"453-460","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Studies in Surgical Trauma: Oxidative Stress in Ischaemia-Reperfusion of Rat Liver"],"prefix":"10.1042","volume":"86","author":[{"given":"P. T.","family":"Liu","sequence":"first","affiliation":[{"name":"School of Biological Sciences, University of Surrey, Guildford, Surrey, U.K., and Trauma Centre, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Symons","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Surrey, Guildford, Surrey, U.K., and Trauma Centre, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. A.","family":"Howarth","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Surrey, Guildford, Surrey, U.K., and Trauma Centre, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. S.","family":"Boulter","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Surrey, Guildford, Surrey, U.K., and Trauma Centre, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. V.","family":"Parke","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, University of Surrey, Guildford, Surrey, U.K., and Trauma Centre, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/86\/4\/453\/464577\/cs0860453.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/86\/4\/453\/464577\/cs0860453.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:48:26Z","timestamp":1638398906000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/86\/4\/453\/76157\/Studies-in-Surgical-Trauma-Oxidative-Stress-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0860453","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4,1]]}}}