{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:19:30Z","timestamp":1760955570571},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,10,1]]},"abstract":"<jats:p>1. The effect of experimental myocardial infarction on exercise and recovery of rat skeletal muscle was studied using 31P n.m.r. 4 weeks post-operatively.<\/jats:p>\n               <jats:p>2. Myocardial infarction (12 \u00b1 3% of left ventricular volume), insufficient to produce haemodynamic manifestations of heart failure, was without significant effect on exercise bioenergetics of skeletal muscle.<\/jats:p>\n               <jats:p>3. Citrate synthase activity was reduced by 17% in the infarcted animals and there was a marked slowing of the rate of phosphocreatine recovery after infarction (half-time 0.7 \u00b1 0.1 min to 1.6 \u00b1 0.2 min) in the absence of evidence of left ventricular failure or hypertrophy.<\/jats:p>\n               <jats:p>4. The study of recovery bioenergetics could provide a more sensitive measure of mitochondrial function than exercise, where no bioenergetic abnormality was detected.<\/jats:p>\n               <jats:p>5. Myocardial infarction can produce evidence of mitochondrial abnormality in skeletal muscle in the absence of haemodynamic compromise.<\/jats:p>","DOI":"10.1042\/cs0870403","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:36:49Z","timestamp":1438947409000},"page":"403-406","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Metabolic Abnormalities in Skeletal Muscle after Myocardial Infarction in the Rat"],"prefix":"10.1042","volume":"87","author":[{"given":"C. H.","family":"Thompson","sequence":"first","affiliation":[{"name":"1MRC Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Headington, Oxford, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. J.","family":"Kemp","sequence":"additional","affiliation":[{"name":"2MRC Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Headington, Oxford, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Rajagopalan","sequence":"additional","affiliation":[{"name":"3MRC Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Headington, Oxford, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. K.","family":"Radda","sequence":"additional","affiliation":[{"name":"4MRC Biochemical and Clinical Magnetic Resonance Unit, John Radcliffe Hospital, Headington, Oxford, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/87\/4\/403\/464728\/cs0870403.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/87\/4\/403\/464728\/cs0870403.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:48:24Z","timestamp":1638398904000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/87\/4\/403\/76156\/Metabolic-Abnormalities-in-Skeletal-Muscle-after"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,10,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0870403","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10,1]]}}}