{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:07:25Z","timestamp":1757700445324},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,10,1]]},"abstract":"<jats:p>1. In the syndrome of inappropriate secretion of antidiuretic hormone, hyponatraemia is associated with a normal bicarbonate concentration despite dilution. This normal bicarbonate concentration is related to the development of a hyperaldosteronism, which is attributed to a direct stimulation of the zona glomerulosa by the hyponatraemic state. Some workers have suggested that, to develop this hyperaldosteronism requires the presence of a pituitary factor. To determine whether the pituitary gland plays a role in this hyponatraemia-induced hyperaldosteronism, water intoxication was performed for 24 h in normal and in panhypopituitaric rats.<\/jats:p>\n               <jats:p>2. In normal rats, hyponatraemia (108 mmol\/l), induced by the administration of 1-desamino-8-D-arginine vasopressin and 2.5% D-glucose-0.45% NaCl by gavage (15% body weight) was associated with a mild increase in bicarbonate concentration, and blood acid-base equilibrium showed a mixed metabolic and respiratory alkalosis (pH 7.57, partial pressure of CO2 29 mmHg, base excess + 5.5 mmol\/l), and aldosterone concentration was increased 3-fold as compared with the control value. When hyponatraemia (110 mmol\/l) was induced in a similar manner in panhypopituitaric rats, we observed a very low aldosterone concentration (&amp;lt; 50 pg\/ml) and a compensated respiratory alkalosis (pH 7.45, partial pressure of CO2 30 mmHg, base excess \u22122.6 mmol\/l). The restoration of a hyperaldosteronaemic state in this group of rats was related essentially to corticosteroid intake.<\/jats:p>\n               <jats:p>3. These data suggest that corticosteroids play a critical role in the development of hyponatraemia-related hyperaldosteronism, a phenomenon not necessarily dependent on a pituitary factor.<\/jats:p>","DOI":"10.1042\/cs0870435","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:36:49Z","timestamp":1438947409000},"page":"435-439","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Restoration by Corticosteroids of the Hyperaldosteronism in Hyponatraemic Rats with Panhypopituitarism"],"prefix":"10.1042","volume":"87","author":[{"given":"G.","family":"Decaux","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Recherche du m\u00e9tabolisme hydromin\u00e9ral, Service de M\u00e9cine Interne, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Crenier","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche du m\u00e9tabolisme hydromin\u00e9ral, Service de M\u00e9cine Interne, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Namias","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche du m\u00e9tabolisme hydromin\u00e9ral, Service de M\u00e9cine Interne, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Gervy","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie, H\u00f4pital Universitaire Erasme, Universit\u00e9 Libre de Bruxelles, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Soupart","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche du m\u00e9tabolisme hydromin\u00e9ral, Service de M\u00e9cine Interne, Brussels, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/87\/4\/435\/464740\/cs0870435.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/87\/4\/435\/464740\/cs0870435.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:48:26Z","timestamp":1638398906000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/87\/4\/435\/76158\/Restoration-by-Corticosteroids-of-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,10,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0870435","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10,1]]}}}