{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:16:59Z","timestamp":1768342619161,"version":"3.49.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,11,1]]},"abstract":"<jats:p>1. The effects of leg muscle pumping (tiptoeing) and tensing (leg-crossing) on orthostatic blood pressure were investigated in six healthy adult subjects (aged 28\u201334 years) and in seven patients with severe hypoadrenergic orthostatic hypotension (aged 20\u201365 years).<\/jats:p>\n               <jats:p>2. Finger arterial pressure was monitored. Relative changes in left ventricular stroke volume were computed by a pulse contour method.<\/jats:p>\n               <jats:p>3. Tiptoeing increased mean arterial pressure (7 \u00b1 5 mmHg) in the healthy subjects, but not in the patients, whereas cardiac output increased in both groups, although by more in the healthy adults than in the patients (35 \u00b1 10% versus 20 \u00b1 11%, P &amp;lt; 0.05). Systemic vascular resistance decreased substantially in both groups while tiptoeing. Leg-crossing did not affect arterial pressure in the healthy subjects, although stroke volume had increased. In contrast, in the patients an increase in cardiac output (16 \u00b1 12%) and mean blood pressure (13 \u00b1 13 mmHg) was observed.<\/jats:p>\n               <jats:p>4. Tiptoeing and leg-crossing have different effects on orthostatic blood pressure in healthy adult subjects and in patients with autonomic failure. In normal humans, tiptoeing increases arterial pressure, whereas leg-crossing has little effect. In the patients, in contrast, tiptoeing has little effect, whereas leg-crossing increases arterial pressure considerably. Patients with autonomic failure should be instructed to apply leg-crossing to combat orthostatic dizziness.<\/jats:p>","DOI":"10.1042\/cs0870553","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:36:49Z","timestamp":1438947409000},"page":"553-558","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Effects of Leg Muscle Pumping and Tensing on Orthostatic Arterial Pressure: A Study in Normal Subjects and Patients with Autonomic Failure"],"prefix":"10.1042","volume":"87","author":[{"given":"A. D. J.","family":"Ten Harkel","sequence":"first","affiliation":[{"name":"1Department of Medicine, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Van Lieshout","sequence":"additional","affiliation":[{"name":"2Department of Medicine, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Wieling","sequence":"additional","affiliation":[{"name":"3Department of Medicine, Academic Medical Centre, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/87\/5\/553\/465202\/cs0870553.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/87\/5\/553\/465202\/cs0870553.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:49:13Z","timestamp":1638398953000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/87\/5\/553\/76219\/Effects-of-Leg-Muscle-Pumping-and-Tensing-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1994,11,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0870553","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,11,1]]}}}