{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:16:20Z","timestamp":1773126980754,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,12,1]]},"abstract":"<jats:p>1. Theoretical and practical considerations suggest that in subjects complaining of fatigue, in the absence of evident organ dysfunction, an alteration in the autonomic nervous system might be present as a functional correlate.<\/jats:p>\n               <jats:p>2. Autoregressive spectral analysis of R-R interval variability from a surface ECG, was used in healthy control subjects (n = 24, age 45 \u00b1 4 years) and in subjects complaining of unexplained fatigue (n = 53, age 46 \u00b1 9 years) to obtain quantitative indices of the state of the sympathovagal balance, both at rest and during a mental stimulus (mental arithmetic), capable of enhancing sympathetic drive. Sympathetic and vagal modulations were inferred from the normalized powers of the low frequency and high frequency spectral components respectively.<\/jats:p>\n               <jats:p>3. We observed in patients, at rest, a prevailing low frequency component of R-R variability (patients low frequency = 73 \u00b1 11, control subjects 51 \u00b1 10 normalized units, P &amp;lt; 0.05). The responsiveness to mental arithmetic was reduced in patients as compared with controls. Systolic blood pressure variability did not differ. This suggested a selective imbalance in autonomic control of the sinoatrial node, characterized by sympathetic predominance as well as by vagal withdrawal, at rest.<\/jats:p>\n               <jats:p>4. The possibility of discriminating patients from control subjects on the basis of simple non-invasive functional markers might provide a better understanding of the mechanisms, clinical evolution and outcome of conditions such as the chronic fatigue syndrome, which lack ordinary evidence of disease, but comprise, as physiopathological correlate, a quantitative alteration of autonomic control.<\/jats:p>","DOI":"10.1042\/cs0870655","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:36:49Z","timestamp":1438947409000},"page":"655-661","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Sympathetic Overactivity in Subjects Complaining of Unexplained Fatigue"],"prefix":"10.1042","volume":"87","author":[{"given":"Massimo","family":"Pagani","sequence":"first","affiliation":[{"name":"Centro Ricerche Cardiovascolari, CNR, Ospedale L Sacco, University of Milano, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Lucini","sequence":"additional","affiliation":[{"name":"Centro Ricerche Cardiovascolari, CNR, Ospedale L Sacco, University of Milano, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe Sandro","family":"Mela","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Genova, Genova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolf","family":"Langewitz","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, University Hospital, Basel, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Malliani","sequence":"additional","affiliation":[{"name":"Centro Ricerche Cardiovascolari, CNR, Ospedale L Sacco, University of Milano, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/87\/6\/655\/494693\/cs0870655.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/87\/6\/655\/494693\/cs0870655.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:49:57Z","timestamp":1638398997000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/87\/6\/655\/76285\/Sympathetic-Overactivity-in-Subjects-Complaining"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1994,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0870655","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,12,1]]}}}