{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:22:23Z","timestamp":1771644143095,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1995,5,1]]},"abstract":"<jats:p>1. Genetic analysis of five kindreds with glucocorticoid-suppressible hyperaldosteronism, four of whom had not been subjected to any previous genetic analysis, revealed three different crossover breakpoints within the five kindreds clustered in the exon 3-intron 4 region of the chimaeric gene. The site of the crossover point had no effect on blood pressure within the kindreds studied.<\/jats:p>\n               <jats:p>2. The gene causing glucocorticoid-suppressible hyperaldosteronism was in strong linkage disequilibrium with an allele of a newly described restriction enzyme polymorphism of the aldosterone synthase gene promoter region, suggesting a possible role for this allele in the development of the chimaeric gene.<\/jats:p>\n               <jats:p>3. A novel observation on subjects inheriting glucocorticoid-suppressible hyperaldosteronism from their mothers showed that they had significantly higher plasma aldosterone concentrations and mean arterial blood pressures than those inheriting glucocorticoid-suppressible hyperaldosteronism from their fathers.<\/jats:p>\n               <jats:p>4. These results raise the possibility that chronic exposure in utero to elevated plasma aldosterone concentrations may result in the permanent programming of mineralocorticoid-dependent blood pressure regulatory mechanisms, which is amplified in later life by the elevated plasma aldosterone concentrations found in glucocorticoid-suppressible hyperaldosteronism.<\/jats:p>","DOI":"10.1042\/cs0880563","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:37:12Z","timestamp":1438947432000},"page":"563-570","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Glucocorticoid-Suppressible Hyperaldosteronism: Effects of Crossover Site and Parental Origin of Chimaeric Gene on Phenotypic Expression"],"prefix":"10.1042","volume":"88","author":[{"given":"Andrew","family":"Jamieson","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics, Western Infirmary, Glasgow, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liliya","family":"Slutsker","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, New York Hospital\u2014Cornell Medical Centre, New York, NY, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon C.","family":"Inglis","sequence":"additional","affiliation":[{"name":"MRC Blood Pressure Group, Western Infirmary, Glasgow, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Fraser","sequence":"additional","affiliation":[{"name":"MRC Blood Pressure Group, Western Infirmary, Glasgow, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perrin C.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, New York Hospital\u2014Cornell Medical Centre, New York, NY, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M. C.","family":"Connell","sequence":"additional","affiliation":[{"name":"MRC Blood Pressure Group, Western Infirmary, Glasgow, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/88\/5\/563\/465266\/cs0880563.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/88\/5\/563\/465266\/cs0880563.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:50:04Z","timestamp":1638399004000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/88\/5\/563\/76291\/Glucocorticoid-Suppressible-Hyperaldosteronism"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0880563","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5,1]]}}}