{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T13:59:15Z","timestamp":1768312755149,"version":"3.49.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1995,10,1]]},"abstract":"<jats:p>1. The ability of diphtheria\u2014tetanus\u2014poliomyelitis\u2014typhoid vaccination to induce modifications in protein metabolism was investigated in post-absorptive healthy humans.<\/jats:p>\n               <jats:p>2. Seven subjects were studied before and 2 days after vaccination. They underwent an intravenous primed constant infusion of l-[1-13C]leucine for 4 h. Plasma protein concentrations, whole-body amino acid fluxes and acute-phase protein synthesis were determined.<\/jats:p>\n               <jats:p>3. Plasma concentrations of fibrinogen, \u03b11-acid glycoprotein, haptoglobin and \u03b11-antitrypsin were significantly elevated 2 days after vaccination (P &amp;lt; 0.05). Leucine oxidation was unaffected but whole-body protein synthesis and breakdown were both increased (P &amp;lt; 0.05), by 25 and 16% respectively, in subjects who had an elevated body temperature (n = 5). Albumin synthesis was unchanged, but hepatic synthesis of fibrinogen was 56% higher after vaccination.<\/jats:p>\n               <jats:p>4. The present investigation indicates that diphtheria\u2014tetanus\u2014poliomyelitis\u2014typhoid vaccination could induce a sustained acute-phase reaction. Moreover, protein metabolism appeared to be extremely sensitive to a mild stress since leucine kinetics and fibrinogen synthesis were affected. Therefore, diphtheria\u2014tetanus\u2014poliomyelitis\u2014typhoid vaccination might represent an attractive model for studying the inflammatory process in humans.<\/jats:p>","DOI":"10.1042\/cs0890389","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:38:13Z","timestamp":1438947493000},"page":"389-396","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Whole-Body Protein Turnover and Hepatic Protein Synthesis Are Increased by Vaccination in Man"],"prefix":"10.1042","volume":"89","author":[{"given":"M.","family":"Cayol","sequence":"first","affiliation":[{"name":"Centre de Recherche de Nutrition Humaine d'Auvergne, Laboratoire d'Etude du M\u00e9tabolisme Azot\u00e9, INRA Theix, Ceyrat, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Tauveron","sequence":"additional","affiliation":[{"name":"Centre de Recherche de Nutrition Humaine d'Auvergne, Laboratoire d'Etude du M\u00e9tabolisme Azot\u00e9, INRA Theix, Ceyrat, France"},{"name":"Service d'Endocrinologie et Maladies M\u00e9taboliques, CHU, Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Rambourdin","sequence":"additional","affiliation":[{"name":"Centre de Recherche de Nutrition Humaine d'Auvergne, Laboratoire d'Etude du M\u00e9tabolisme Azot\u00e9, INRA Theix, Ceyrat, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Prugnaud","sequence":"additional","affiliation":[{"name":"Centre de Recherche de Nutrition Humaine d'Auvergne, Laboratoire d'Etude du M\u00e9tabolisme Azot\u00e9, INRA Theix, Ceyrat, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Gachon","sequence":"additional","affiliation":[{"name":"Laboratoire de Nutrition Humaine and INSERM U71, Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Thieblot","sequence":"additional","affiliation":[{"name":"Service d'Endocrinologie et Maladies M\u00e9taboliques, CHU, Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Grizard","sequence":"additional","affiliation":[{"name":"Centre de Recherche de Nutrition Humaine d'Auvergne, Laboratoire d'Etude du M\u00e9tabolisme Azot\u00e9, INRA Theix, Ceyrat, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Obled","sequence":"additional","affiliation":[{"name":"Centre de Recherche de Nutrition Humaine d'Auvergne, Laboratoire d'Etude du M\u00e9tabolisme Azot\u00e9, INRA Theix, Ceyrat, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/89\/4\/389\/465936\/cs0890389.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/89\/4\/389\/465936\/cs0890389.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:52:05Z","timestamp":1638399125000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/89\/4\/389\/76431\/Whole-Body-Protein-Turnover-and-Hepatic-Protein"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,10,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0890389","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,10,1]]}}}