{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T16:20:21Z","timestamp":1773418821186,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,2,1]]},"abstract":"<jats:p>1. To further investigate the role of microvascular functional changes in the pathogenesis of diabetic microangiopathy in type 1 diabetes, microvascular fluid permeability was measured in nine patients with a long disease duration and no or minimal (background retinopathy alone) microangiopathy, nine age-, sex- and duration-matched patients with microalbuminuria and nine control subjects. Microvascular fluid permeability was assessed by determination of the forearm capillary filtration coefficient using a sensitive strain-gauge plethysmographic technique.<\/jats:p>\n               <jats:p>2. Microvascular fluid permeability was significantly higher in the patients with microalbuminuria [8.5 (6.8\u201315.2) \u00d7 10\u22123 ml min\u22121 100 g\u22121 of tissue mmHg\u22121; median (range)] than in the patients with no or minimal complications [5.2 (3.6\u20137.0) \u00d7 10\u22123 ml min\u22121 100 g\u22121 of tissue mmHg\u22121, P &amp;lt; 0.001]. There was, however, no significant difference in microvascular fluid permeability between the patients with no or minimal complications and control subjects [4.5 (3.2\u20135.7) \u00d7 10\u22123 ml min\u22121 100 g\u22121 of tissue mmHg\u22121, P = 0.31]. Blood pressure and glycaemic control were similar in the two groups of diabetic patients.<\/jats:p>\n               <jats:p>3. These results provide further evidence that changes in microvascular permeability are found in other vascular beds in patients with incipient nephropathy, whereas no such changes are found in patients with a long disease duration and little evidence of microangiopathy.<\/jats:p>","DOI":"10.1042\/cs0900113","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:38:46Z","timestamp":1438947526000},"page":"113-117","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Differences in Microvascular Fluid Permeability between Long-Duration Type 1 (Insulin-Dependent) Diabetic Patients with and without Significant Microangiopathy"],"prefix":"10.1042","volume":"90","author":[{"given":"Alan J.","family":"Jaap","sequence":"first","affiliation":[{"name":"Department of Diabetes and Vascular Medicine, Postgraduate Medical School, University of Exeter, Exeter, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela C.","family":"Shore","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Vascular Medicine, Postgraduate Medical School, University of Exeter, Exeter, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Tooke","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Vascular Medicine, Postgraduate Medical School, University of Exeter, Exeter, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/90\/2\/113\/465817\/cs0900113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/90\/2\/113\/465817\/cs0900113.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:52:57Z","timestamp":1638399177000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/90\/2\/113\/76486\/Differences-in-Microvascular-Fluid-Permeability"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,2,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0900113","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,2,1]]}}}