{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:27:49Z","timestamp":1771626469083,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1996,3,1]]},"abstract":"<jats:p>1. The influence of central inspiratory drive on heart rate variability was investigated in young human subjects using power spectral analysis of R\u2014R intervals.<\/jats:p>\n               <jats:p>2. The area of the high-frequency component occurring at the respiratory frequency (0.2\u20130.25 Hz) in the power spectral density curves was used as an index of respiratory sinus arrhythmia.<\/jats:p>\n               <jats:p>3. Central inspiratory drive was increased by breathing a CO2-enriched (5%) gas mixture and this condition was compared with a similar degree of ventilation produced voluntarily.<\/jats:p>\n               <jats:p>4. Tests were conducted on eight young subjects with and without low-dose scopolamine (scopoderm TTS) in a double-blind cross-over trial.<\/jats:p>\n               <jats:p>5. Scopolamine decreased heart rate and increased the high-frequency peak, suggesting that its main action on the cardiac vagal pathway was a peripheral one, possibly increasing the efficacy of vagal impulses on the cardiac pacemaker.<\/jats:p>\n               <jats:p>6. With scopolamine, CO2 breathing increased the area of the high-frequency component significantly more than a similar degree of ventilatory movements produced by voluntary hyperventilation.<\/jats:p>\n               <jats:p>7. It is concluded that respiratory sinus arrhythmia in humans is at least partly dependent on a central respiratory\u2014cardiac coupling, most probably similar to that shown in animal studies.<\/jats:p>","DOI":"10.1042\/cs0900235","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:38:46Z","timestamp":1438947526000},"page":"235-241","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Respiratory Sinus Arrhythmia and Central Respiratory Drive in Humans"],"prefix":"10.1042","volume":"90","author":[{"given":"M.","family":"Al-Ani","sequence":"first","affiliation":[{"name":"Department of Physiology Birmingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. S.","family":"Forkins","sequence":"additional","affiliation":[{"name":"Department of Physiology Birmingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. N.","family":"Townend","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Birmingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Coote","sequence":"additional","affiliation":[{"name":"Department of Physiology Birmingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/90\/3\/235\/488230\/cs0900235.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/90\/3\/235\/488230\/cs0900235.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:55:36Z","timestamp":1638399336000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/90\/3\/235\/76611\/Respiratory-Sinus-Arrhythmia-and-Central"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0900235","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,3,1]]}}}