{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T14:38:58Z","timestamp":1721918338136},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,5,1]]},"abstract":"<jats:p>1. It has been suggested that local tissue renin\u2014angiotensin systems may be activated in heart failure and that effects on such systems may, at least partially, explain the beneficial effects of angiotensin-converting enzyme (ACE) inhibitors in this syndrome. To investigate these hypotheses, we examined expression of renin-angiotensin system components in several tissues in a rodent model of post-myocardial infarction (MI) heart failure, and analysed whether such expression is modified by ACE inhibitor treatment.<\/jats:p>\n               <jats:p>2. Four groups of rats (n = 8\u201312 per group) were studied 30 days after surgery: (A) sham-operated rats with no treatment, (B) rats with post-MI heart failure induced by ligation of the left coronary artery, (C) sham-operated rats treated with the ACE inhibitor perindopril (1.5 mg day\u22121 kg\u22121), and (D) rats as per B, but treated with perindopril. Expression of renin, angiotensinogen, ACE and angiotensin subtype 1 receptor was assessed by quantification of their respective mRNAs by Northern blotting.<\/jats:p>\n               <jats:p>3. Renal renin mRNA increased 2-fold in animals with MI (group B) compared with controls (group A) (P &amp;lt; 0.05) and between 50 and 100-fold after ACE inhibitor treatment (P &amp;lt; 0.001). No change in renin gene expression was found in any extra-renal site either following MI or after ACE inhibitor treatment. Hepatic angiotensinogen mRNA level was similar in all groups, but kidney angiotensinogen mRNA level was increased 1.6-fold (P &amp;lt; 0.01) in the groups receiving perindopril. ACE mRNA level in the lung was not affected by ACE inhibitor treatment but decreased by 50% following MI (groups B and D, P &amp;lt; 0.01). This was associated with a similar (50%, P &amp;lt; 0.01) fall in lung ACE activity and was correlated with the severity of heart failure. Angiotensin subtype 1 receptor mRNA level was not affected in any tissue by either MI or ACE inhibitor treatment.<\/jats:p>\n               <jats:p>4. We did not find a systematic activation of tissue renin-angiotensin systems, as assessed by steady-state mRNA levels of key components of the system in experimental post-MI heart failure, or a major effect of ACE inhibitor treatment on expression of these components. However, we observed tissue-specific changes in expression of selected components of the renin-angiotensin system in the kidney and the lung in post-MI heart failure and after ACE inhibitor treatment, which may be of relevance to the pathophysiology of the syndrome and the effects of ACE inhibition.<\/jats:p>","DOI":"10.1042\/cs0920455","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:39:42Z","timestamp":1438947582000},"page":"455-465","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Tissue Expression of Components of the Renin\u2014Angiotensin System in Experimental Post-Infarction Heart Failure in Rats: Effects of Heart Failure and Angiotensin-Converting Enzyme Inhibitor Treatment"],"prefix":"10.1042","volume":"92","author":[{"given":"Martin P.","family":"Kelly","sequence":"first","affiliation":[{"name":"Department of Cardiology, University of Leicester, Leicester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"OLE","family":"Kahr","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, University of Aarhus, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Aalkjaer","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, University of Aarhus, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Cumin","sequence":"additional","affiliation":[{"name":"Ciba-Geigy Ltd, Basle, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilesh J","family":"Samani","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Leicester, Leicester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/92\/5\/455\/466532\/cs0920455.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/92\/5\/455\/466532\/cs0920455.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:57:31Z","timestamp":1638399451000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/92\/5\/455\/76696\/Tissue-Expression-of-Components-of-the-Renin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0920455","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,5,1]]}}}