{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:07:51Z","timestamp":1783480071133,"version":"3.55.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,8,1]]},"abstract":"<jats:p>1. This study aimed to investigate the possible role of leptin in post-traumatic anorexia by making pre- and post-operative (0\u20138 days) measurements of circulating leptin concentrations in six patients undergoing elective total hip replacement for osteoarthritis.<\/jats:p>\n               <jats:p>2. Mean daily hunger rating (four categories) and food intake (assessed by food record charts) were measured pre-operatively, as well as post-operatively for the first 5 days (days 0\u20135). Leptin concentrations, circulating metabolites [glucose, non-esterified fatty acids, glutamine and 3-hydroxy-butyrate] and insulin and cortisol concentrations were measured pre-operatively (day 0) and post-operatively (days 1, 2, 3, 5 and 8).<\/jats:p>\n               <jats:p>3. Mean leptin concentrations were significantly increased only on day 1 (56% increase compared with pre-operative values, P &amp;lt; 0.009), whereas food intake (only 0.6 MJ on day 0) and hunger (5\/6 patients \u2018not hungry\u2019 on day 0) only gradually improved over the next few days. (The energy intake over the first 5 days was 56% of the pre-operative value.)<\/jats:p>\n               <jats:p>4. Circulating insulin and cortisol concentrations were elevated on day 1 compared with pre-operative values on day 0 (P&amp;lt;0.05). Of the measured metabolites implicated in the control of food intake, circulating non-esterified fatty acids and 3-hydroxybutyrate were not significantly altered in the post-operative period, but significant hyper-glycaemia was noted on day 1 compared with day 0 pre-operatively (8.8 compared with 6.4 mmol\/l glucose; P &amp;lt; 0.01).<\/jats:p>\n               <jats:p>5. It is concluded that circulating leptin is involved in the early (&amp;lt;24 h) acute-phase response after moderately severe surgical trauma (characterized biochemically by a substantial acute-phase protein response, hypoalbuminaemia, hyperglycaemia and hypoglutaminaemia). Therefore, leptin may be implicated in post-traumatic anorexia, although other factors are likely to be involved, especially after the first 24 h when circulating leptin concentrations are no longer elevated.<\/jats:p>","DOI":"10.1042\/cs0930113","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:39:55Z","timestamp":1438947595000},"page":"113-117","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Plasma Leptin, Energy Intake and Hunger following Total Hip Replacement Surgery"],"prefix":"10.1042","volume":"93","author":[{"given":"Rebecca J.","family":"Stratton","sequence":"first","affiliation":[{"name":"M.R.C. Dunn Clinical Nutrition Centre, Hills Road, Cambridge CB2 2DH, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Dewit","sequence":"additional","affiliation":[{"name":"M.R.C. Dunn Clinical Nutrition Centre, Hills Road, Cambridge CB2 2DH, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Crowe","sequence":"additional","affiliation":[{"name":"M.R.C. Dunn Clinical Nutrition Centre, Hills Road, Cambridge CB2 2DH, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Jennings","sequence":"additional","affiliation":[{"name":"M.R.C. Dunn Clinical Nutrition Centre, Hills Road, Cambridge CB2 2DH, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard N.","family":"Villar","sequence":"additional","affiliation":[{"name":"Cambridge Hip and Knee Unit, BUPA Cambridge Lea Hospital, 30 New Road, Cambridge CB4 4EL, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinos","family":"Elia","sequence":"additional","affiliation":[{"name":"M.R.C. Dunn Clinical Nutrition Centre, Hills Road, Cambridge CB2 2DH, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/93\/2\/113\/466633\/cs0930113.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/93\/2\/113\/466633\/cs0930113.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:58:52Z","timestamp":1638399532000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/93\/2\/113\/76727\/Plasma-Leptin-Energy-Intake-and-Hunger-following"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0930113","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8,1]]}}}