{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T22:00:38Z","timestamp":1775080838647,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,8,1]]},"abstract":"<jats:p>1. Travellers to high altitude often complain of paroxysmal cough, which has not been previously investigated. We recorded overnight cough frequency and cough-receptor sensitivity to inhaled citric acid in a group of climbers travelling to 5300 m or higher.<\/jats:p>\n               <jats:p>2. Cough frequency, monitored in ten subjects, increased from a median of 0 coughs at sea level (range 0\u20131) to 5 coughs at 5000 m (range 0\u201313) and to over 60 coughs in subjects ascending to 7000 m. Citric acid cough threshold, measured in 42 subjects, was unchanged on arrival at 5300 m compared with sea level (geometric mean difference 1.26, 95% confidence intervals 0.84\u20131.89, P = 0.25), but was significantly reduced after 6 days, or more, at altitude compared with sea level (geometric mean difference 2.2, 95% confidence intervals 1.54\u20133.15, P = 0.0002). Cough threshold was not related to symptoms of acute mountain sickness, oxygen saturation, carbon dioxide tension or lung function.<\/jats:p>\n               <jats:p>3. These results indicate an increase in cough and cough-receptor sensitivity after some days at altitude. This may be due to respiratory tract damage from breathing cold dry air at increased ventilatory rates. Other explanations, such as sub-clinical pulmonary oedema or an effect on the cough centre of acclimatization to altitude, cannot be excluded.<\/jats:p>","DOI":"10.1042\/cs0930181","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:39:55Z","timestamp":1438947595000},"page":"181-186","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cough Frequency and Cough-Receptor Sensitivity are Increased in Man at Altitude"],"prefix":"10.1042","volume":"93","author":[{"given":"P.W.","family":"Barry","sequence":"first","affiliation":[{"name":"Department of Child Health, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, PO Box 65, Leicester LE2 7LX, U.K."},{"name":"British Mount Everest Medical Expedition, The Pinfolds, Hyssington, Powys, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.P.","family":"Mason","sequence":"additional","affiliation":[{"name":"British Mount Everest Medical Expedition, The Pinfolds, Hyssington, Powys, U.K."},{"name":"Service D'Anesth\u00e9sie-R\u00e9animation, H\u00f4pital Tenon, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Riordan","sequence":"additional","affiliation":[{"name":"Department of Child Health, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, PO Box 65, Leicester LE2 7LX, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"O'Callaghan","sequence":"additional","affiliation":[{"name":"Department of Child Health, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, PO Box 65, Leicester LE2 7LX, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/93\/2\/181\/466645\/cs0930181.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/93\/2\/181\/466645\/cs0930181.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:59:32Z","timestamp":1638399572000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/93\/2\/181\/76738\/Cough-Frequency-and-Cough-Receptor-Sensitivity-are"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0930181","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,8,1]]}}}