{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T00:53:25Z","timestamp":1696035205331},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,4,1]]},"abstract":"<jats:p>1. Twenty-seven young subjects used their right hand to perform sustained, isometric contractions at 40% of maximum for 2 min while lying supine.<\/jats:p>\n               <jats:p>2. During the last 30 s of exercise, mean arterial blood pressure increased by 38 \u00b1 4 mmHg (mean \u00b1 S.E.M.) and heart rate by 27 \u00b1 2 beats\/min.<\/jats:p>\n               <jats:p>3. Nineteen of the subjects respired eucapnically during exercise, increasing ventilation by 4.1 \u00b1 0.5 litres\/min. Eight subjects hyperventilated (7.1\u201319.6 litres\/min) and decreased end-tidal Pco2 by 8.2 to 15.1 mmHg during the last minute of exercise.<\/jats:p>\n               <jats:p>4. In the eucapnic subjects mean flow velocity in the right (i.e. contralateral to the activated cortex) middle cerebral artery increased by 11.4 \u00b1 1.0 cm\/s, a change of 17%, during the contraction. This represents an increase in volume flow to the territory of this vessel, but an increase in global flow to the brain cannot be inferred.<\/jats:p>\n               <jats:p>5. In the eight subjects who hyperventilated during exercise, there was no rise of flow velocity in the middle cerebral artery, and in some subjects there was a fall during the first 2 min of recovery. These findings suggest that if subjects hyperventilate during handgrip exercise there could be a fall in volume flow to many regions of the brain during and after the exercise.<\/jats:p>","DOI":"10.1042\/cs0940353","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:40:13Z","timestamp":1438947613000},"page":"353-358","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cerebral Blood Flow Velocity during and after Sustained Isometric Skeletal Muscle Contractions in Man"],"prefix":"10.1042","volume":"94","author":[{"given":"F. J.","family":"Imms","sequence":"first","affiliation":[{"name":"Sherrington School of Physiology, United Medical and Dental Schools (St Thomas's Campus), London SE1 7EH, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Russo","sequence":"additional","affiliation":[{"name":"Division of Surgery, United Medical and Dental Schools (St Thomas's Campus), London SE1 7EH, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. I.","family":"Iyawe","sequence":"additional","affiliation":[{"name":"Sherrington School of Physiology, United Medical and Dental Schools (St Thomas's Campus), London SE1 7EH, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. B.","family":"Segal","sequence":"additional","affiliation":[{"name":"Sherrington School of Physiology, United Medical and Dental Schools (St Thomas's Campus), London SE1 7EH, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/94\/4\/353\/466824\/cs0940353.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/94\/4\/353\/466824\/cs0940353.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T23:14:19Z","timestamp":1638400459000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/94\/4\/353\/76900\/Cerebral-Blood-Flow-Velocity-during-and-after"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0940353","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,4,1]]}}}