{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T03:59:35Z","timestamp":1767153575045,"version":"build-2238731810"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1999,12,1]]},"abstract":"<jats:p>The aim of this investigation was to study the effects of isoglycaemic hyperinsulinaemia on the renal metabolism of electrolytes and water in subjects with a strong genetic predisposition to essential hypertension, compared with that in non-predisposed subjects. We studied 25 normotensive subjects aged 18\u201335 years whose parents both had essential hypertension, and 22 age- and sex-matched subjects whose parents were both normotensive. Diabetes or morbid obesity in any subject or parent excluded the family. The 24-h blood pressure was measured. The subjects received an isocaloric diet with a fixed content of sodium and potassium for 4 days before the study. An isoglycaemic, hyperinsulinaemic clamp with infusion of insulin (40 munits\u00b7min-1\u00b7m-2) was performed. We measured the renal clearance of diethylenetriaminepenta-acetic acid, sodium, potassium and lithium both under basal conditions and during hyperinsulinaemia. In response to hyperinsulinaemia, renal sodium clearance decreased to a significantly greater extent in the hypertension-prone subjects [0.57 (0.74, 0.36) ml\u00b7min-1\u00b71.73 m2 (median and quartiles)] than in the controls [0.34 (0.56, 0.18) ml\u00b7min-1\u00b71.73 m2] (P = 0.04). Compared with the controls, the subjects predisposed to hypertension had a higher 24-h diastolic blood pressure [78 (70, 82) mmHg, compared with 73 (68, 77) mmHg], but a similar insulin sensitivity index {107\u00d7[313 (225, 427)] compared with 107\u00d7[354 (218, 435)] l2\u00b7min-1\u00b7pmol-1\u00b7kg-1}. Thus the sodium-retaining effect of insulin was more pronounced in subjects with a strong genetic predisposition to essential hypertension than in subjects with normotensive parents. This effect may contribute to the development of hypertension in subjects with a genetic predisposition to hypertension.<\/jats:p>","DOI":"10.1042\/cs0970681","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T07:41:12Z","timestamp":1438933272000},"page":"681-687","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Renal effects of hyperinsulinaemia in subjects with two hypertensive parents"],"prefix":"10.1042","volume":"97","author":[{"given":"Ulrik B.","family":"ANDERSEN","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Hvidovre Hospital, DK-2650 Hvidovre, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"SK\u00d8TT","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Herlev Hospital, DK-2730 Herlev, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels E.","family":"BRUUN","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Gentofte Hospital, DK-2900 Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harriet","family":"DIGE-PETERSEN","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, DK-2600 Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"IBSEN","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Glostrup Hospital, DK-2600 Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[1999,11,15]]},"container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/97\/6\/681\/467726\/cs0970681.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/portlandpress.com\/clinsci\/article-pdf\/97\/6\/681\/467726\/cs0970681.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,14]],"date-time":"2023-05-14T20:15:37Z","timestamp":1684095337000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/97\/6\/681\/77215\/Renal-effects-of-hyperinsulinaemia-in-subjects"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11,15]]},"references-count":0,"aliases":["10.1042\/cs19990123"],"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0970681","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11,15]]}}}