{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T17:40:36Z","timestamp":1649094036468},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s2002","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,9,1]]},"abstract":"<jats:p>The use of cyclosporin A (CsA) in solid organ transplantation has been shown to be associated with the development of hypertension and nephrotoxicity. Several mechanisms, including endothelin (ET)-1-mediated systemic vasoconstriction, are considered to be responsible for CsA-induced hypertension. This study shows that: (i) incubation of CsA (1\u00b5M) with bovine aortic endothelial cells leads to increased ET secretion by+40%; (ii) the use of compactin, the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and fibric acid, the peroxisome-proliferator-activated receptor (PPAR)-alpha activator, inhibit the CsA-induced ET secretion to the level below the basal ET secretion, by -32% and -26% respectively; (iii) both inhibitions were reversed by the addition of mevalonate, suggesting communication between the HMG-CoA reductase product and PPAR-alpha pathway. The present findings may be of significant clinical relevance, since statins and fibrates beyond their hypolipidaemic action may represent a potential therapeutic tool in the treatment or prophylaxis of CsA-associated side effects. Furthermore, we suggest that the mevalonate metabolism would interfere with PPAR-alpha activity.<\/jats:p>","DOI":"10.1042\/cs103s081s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:43:51Z","timestamp":1438947831000},"page":"81S-83S","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["HMG-CoA reductase inhibition and PPAR-alpha activation both inhibit cyclosporin A induced endothelin-1 secretion in cultured endothelial cells"],"prefix":"10.1042","volume":"103","author":[{"given":"Abdelmejid","family":"KANDOUSSI","sequence":"first","affiliation":[{"name":"D\u00e9partement de Recherches sur les Lipoprot\u00e9ines et l'Ath\u00e9roscl\u00e9rose, Inserm U545, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019, Lille, France"},{"name":"Universit\u00e9 de Lille 2, Facult\u00e9 de Pharmacie, 3 rue du Professeur Laguesse, BP 83, 59006 cedex Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7ois","family":"MARTIN","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Recherches sur les Lipoprot\u00e9ines et l'Ath\u00e9roscl\u00e9rose, Inserm U545, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019, Lille, France"},{"name":"Universit\u00e9 de Lille 2, Facult\u00e9 de Pharmacie, 3 rue du Professeur Laguesse, BP 83, 59006 cedex Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"HAZZAN","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Recherches sur les Lipoprot\u00e9ines et l'Ath\u00e9roscl\u00e9rose, Inserm U545, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"NO\u00cbL","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Recherches sur les Lipoprot\u00e9ines et l'Ath\u00e9roscl\u00e9rose, Inserm U545, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019, Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Charles","family":"FRUCHART","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Recherches sur les Lipoprot\u00e9ines et l'Ath\u00e9roscl\u00e9rose, Inserm U545, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019, Lille, France"},{"name":"Universit\u00e9 de Lille 2, Facult\u00e9 de Pharmacie, 3 rue du Professeur Laguesse, BP 83, 59006 cedex Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart","family":"STAELS","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Recherches sur les Lipoprot\u00e9ines et l'Ath\u00e9roscl\u00e9rose, Inserm U545, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019, Lille, France"},{"name":"Universit\u00e9 de Lille 2, Facult\u00e9 de Pharmacie, 3 rue du Professeur Laguesse, BP 83, 59006 cedex Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"DURIEZ","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Recherches sur les Lipoprot\u00e9ines et l'Ath\u00e9roscl\u00e9rose, Inserm U545, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019, Lille, France"},{"name":"Universit\u00e9 de Lille 2, Facult\u00e9 de Pharmacie, 3 rue du Professeur Laguesse, BP 83, 59006 cedex Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/103\/s2002\/81S\/440270\/cs103s081s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/103\/s2002\/81S\/440270\/cs103s081s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:20:45Z","timestamp":1638397245000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/103\/s2002\/81S\/69733\/HMG-CoA-reductase-inhibition-and-PPAR-alpha"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9,1]]},"references-count":0,"journal-issue":{"issue":"s2002","published-print":{"date-parts":[[2002,9,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs103s081s","relation":{},"ISSN":["0143-5221"],"issn-type":[{"value":"0143-5221","type":"print"}],"subject":[],"published":{"date-parts":[[2002,9,1]]}}}