{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T17:51:59Z","timestamp":1719251519989},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s2002","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,9,1]]},"abstract":"<jats:p>The incidence of ventricular tachyarrhythmias in the early post-operative period following implantable cardioverter-defibrillator (ICD) implantation is relatively high compared with that in control periods. Since endothelin-1 (ET-1) has been proven to be an endogenous arrhythmogenic substance, we investigated the changes in serum ET-1 and big-ET levels in patients undergoing ICD implantation. Serum concentrations of ET-1 and big-ET were measured in 14 patients with various heart diseases before the operation, as well as 1min and 1h after the last shock therapy. Big-ET levels and the sum of ET-1 and big-ET levels were unchanged immediately after the operation, but had increased significantly by 1h after implantation (before, 1.57\u00b10.61pmol\/l; 1min, 1.86\u00b10.87pmol\/l; 1h, 4.29\u00b11.65pmol\/l for big-ET; before, 3.44\u00b11.07pmol\/l; 1min, 3.79\u00b11.29pmol\/l; 1h, 6.36\u00b12.03pmol\/l for big-ET+ET-1). There was a significant correlation between left ventricular ejection fraction and big-ET level measured 1h after the last shock delivery (r =-0.542, P&amp;lt;0.05). We conclude that the increased big-ET level observed 1h after the last induction and shock therapy of ventricular fibrillation might have a pathophysiological role in the increased incidence of post-operative spontaneous ventricular arrhythmias.<\/jats:p>","DOI":"10.1042\/cs103s233s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:43:51Z","timestamp":1438947831000},"page":"233S-236S","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of implantable cardioverter defibrillator implantation and shock application on serum endothelin-1 and big-endothelin levels"],"prefix":"10.1042","volume":"103","author":[{"given":"Andrea","family":"SZ\u00dcCS","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Semmelweis University, V\u00e1rosmajor u. 68. H-1122 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katalin","family":"KELTAI","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Semmelweis University, V\u00e1rosmajor u. 68. H-1122 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Endre","family":"ZIMA","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Semmelweis University, V\u00e1rosmajor u. 68. H-1122 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajnalka","family":"V\u00c1G\u00d3","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Semmelweis University, V\u00e1rosmajor u. 68. H-1122 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e1l","family":"SO\u00d3S","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Semmelweis University, V\u00e1rosmajor u. 68. H-1122 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Attila","family":"R\u00d3KA","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Semmelweis University, V\u00e1rosmajor u. 68. H-1122 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zolt\u00e1n","family":"SZABOLCS","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Semmelweis University, V\u00e1rosmajor u. 68. H-1122 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00e1szl\u00f3","family":"GELL\u00c9R","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Semmelweis University, V\u00e1rosmajor u. 68. H-1122 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9la","family":"MERKELY","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Semmelweis University, V\u00e1rosmajor u. 68. H-1122 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/103\/s2002\/233S\/440109\/cs103s233s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/103\/s2002\/233S\/440109\/cs103s233s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:18:56Z","timestamp":1638397136000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/103\/s2002\/233S\/69571\/Effects-of-implantable-cardioverter-defibrillator"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9,1]]},"references-count":0,"journal-issue":{"issue":"s2002","published-print":{"date-parts":[[2002,9,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs103s233s","relation":{},"ISSN":["0143-5221"],"issn-type":[{"value":"0143-5221","type":"print"}],"subject":[],"published":{"date-parts":[[2002,9,1]]}}}