{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T08:31:54Z","timestamp":1768552314927,"version":"3.49.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s2002","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,9,1]]},"abstract":"<jats:p>In diabetes mellitus, there is a problem of both premature atherosclerosis as well as impaired collateralization. Studies were performed using the rat corneal angiogenesis model as a surrogate for collateralization to determine the effect of diabetes mellitus on endothelin (ET)-1, ET-3, vascular endothelial growth factor (VEGF) and interleukin-8 (IL-8)-mediated angiogenesis. In an initial group of experiments, streptozotocin-induced diabetes resulted in impairment of ET-1-mediated angiogenesis from 69% to 32%, but was only impaired from 74% to 59% for ET-3. When rats were fluid-resuscitated, mortality fell, and the incidence of inhibition of angiogenesis decreased for ET-1, but was still at 47%. Inhibition of ET-3-mediated angiogenesis in fluid-resuscitated rats was essentially unaffected from 74% to 75%. Studies of VEGF and IL-8 in fluid-resuscitated rats demonstrated that VEGF-mediated angiogenesis was only inhibited from 49% to 45%, but there was inhibition of IL-8-mediated angiogenesis from 62% to 31%. We concluded that there may be two mechanisms by which ET-1-mediated corneal angiogenesis is inhibited: a decrease in intravascular volume and dynamic forces affecting angiogenesis, and a direct effect of diabetes on some aspect of cell growth or angiogenic process. Diabetes also appeared to inhibit IL-8-mediated angiogenesis, but had very little or no effect on ET-3- or VEGF-mediated angiogenesis.<\/jats:p>","DOI":"10.1042\/cs103s424s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:43:51Z","timestamp":1438947831000},"page":"424S-429S","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The effect of diabetes on endothelin, interleukin-8 and vascular endothelial growth factor-mediated angiogenesis in rats"],"prefix":"10.1042","volume":"103","author":[{"given":"Eugene L.","family":"BEK","sequence":"first","affiliation":[{"name":"Department of Surgery, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554 U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marvin A.","family":"MCMILLEN","sequence":"additional","affiliation":[{"name":"Department of Surgery, Beth Israel Medical Center, 16th at 1st Avenue, New York, NY 10003, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"SCOTT","sequence":"additional","affiliation":[{"name":"Department of Surgery, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554 U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. D. George","family":"ANGUS","sequence":"additional","affiliation":[{"name":"Department of Surgery, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554 U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald W.","family":"SHAFTAN","sequence":"additional","affiliation":[{"name":"Department of Surgery, Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554 U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/103\/s2002\/424S\/440232\/cs103s424s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/103\/s2002\/424S\/440232\/cs103s424s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:20:00Z","timestamp":1638397200000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/103\/s2002\/424S\/69655\/The-effect-of-diabetes-on-endothelin-interleukin-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9,1]]},"references-count":0,"journal-issue":{"issue":"s2002","published-print":{"date-parts":[[2002,9,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs103s424s","relation":{},"ISSN":["0143-5221"],"issn-type":[{"value":"0143-5221","type":"print"}],"subject":[],"published":{"date-parts":[[2002,9,1]]}}}