{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T06:36:14Z","timestamp":1781937374805,"version":"3.54.5"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,1,1]]},"abstract":"<jats:p>The direct vasodilatory and negative chronotropic effects of adenosine in humans are counterbalanced by a reflex increase in sympathetic nerve traffic. A suggested mechanism for this reflex includes peripheral chemoreceptor activation. We, therefore, assessed the contribution of carotid chemoreceptors to sympatho-excitation by adenosine. Muscle sympathetic nerve activity was recorded during adenosine infusion (140 \u00b5g\u00b7kg-1\u00b7min-1 for 5 min) in five patients lacking carotid chemoreceptors after bilateral carotid body tumour resection (one male and four female, mean age 51\u00b111 years) and in six healthy controls (two male and four female, mean age 50\u00b17 years). Sympathetic responses to sodium nitroprusside injections were assessed to measure baroreceptor-mediated sympathetic activation. In response to adenosine, controls showed no change in blood pressure, an increase in heart rate (+48.2\u00b113.2%; P&amp;lt;0.003) and an increase in sympathetic nerve activity (+195\u00b1103%; P&amp;lt;0.022). In contrast, patients showed a decrease in blood pressure (-14.6\u00b14.9\/-17.6\u00b16.0%; P&amp;lt;0.05), an increase in heart rate (+25.3\u00b18.4%; P&amp;lt;0.032) and no significant change in sympathetic activity. Adenosine-induced hypotension in individual patients elicited less sympathetic activation than equihypotensive sodium nitroprusside injections. In humans lacking carotid chemoreceptors, adenosine infusion elicits hypotension due to the absence of significant sympatho-excitation. Chemoreceptor activation is essential for counterbalancing the direct vasodilation by adenosine. In addition, blunting of the baroreflex sympathetic response to adenosine-induced hypotension may indicate a direct sympatho-inhibitory effect of adenosine.<\/jats:p>","DOI":"10.1042\/cs20030174","type":"journal-article","created":{"date-parts":[[2004,1,22]],"date-time":"2004-01-22T12:53:13Z","timestamp":1074775993000},"page":"75-82","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The role of carotid chemoreceptors in the sympathetic activation by adenosine in humans"],"prefix":"10.1042","volume":"106","author":[{"given":"Henri J. L. M.","family":"TIMMERS","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard A.","family":"RONGEN","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"KAREMAKER","sequence":"additional","affiliation":[{"name":"Department of Physiology, Academic Medical Center, PO Box 22660, 1100DD Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wouter","family":"WIELING","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Academic Medical Center, PO Box 22660, 1100DD Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henri A. M.","family":"MARRES","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques W. M.","family":"LENDERS","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/106\/1\/75\/434630\/cs1060075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/106\/1\/75\/434630\/cs1060075.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T20:30:35Z","timestamp":1638390635000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/106\/1\/75\/67720\/The-role-of-carotid-chemoreceptors-in-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20030174","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1,1]]}}}