{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:08:31Z","timestamp":1787004511249,"version":"build-2736575974"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,4,1]]},"abstract":"<jats:p>Folic acid supplementation lowers total plasma homocysteine (tHcy) and improves endothelial function in individuals with coronary artery disease (CAD) and in those with additional CAD risk factors. In the present study, we assessed whether endothelial function is impaired in healthy subjects with hyperhomocysteinaemia but without other CAD risk factors and whether folic acid supplementation improves endothelial function in these subjects. Flow-mediated dilatation (FMD) of the brachial artery was performed on 26 healthy subjects, age 49\u00b12 years (mean\u00b1S.E.M.), with high tHcy (15.6\u00b11.5 \u00b5mol\/l) and 16 healthy age-matched subjects with low tHcy (7.9\u00b10.6 \u00b5mol\/l; P&amp;lt;0.001). Subjects with high tHcy were then randomized to receive 5 mg\/day of folic acid or placebo for 8 weeks in a double-blind cross-over trial with a 4-week washout. FMD was not associated with tHcy and was not different between high and low tHcy groups (7.0\u00b10.6% compared with 6.6\u00b11.2%, P=0.76). Treatment with folic acid decreased tHcy by 34% in hyperhomocysteinaemic subjects (P=0.02 compared with placebo), but had no effect on FMD (+0.5\u00b10.6% compared with -0.7\u00b10.5%; P=0.17 compared with placebo). In healthy subjects with hyperhomocysteinaemia, but without additional cardiovascular risk, endothelial function is unimpaired and folic acid supplementation has no additional effect.<\/jats:p>","DOI":"10.1042\/cs20030296","type":"journal-article","created":{"date-parts":[[2004,4,13]],"date-time":"2004-04-13T10:44:17Z","timestamp":1081853057000},"page":"353-358","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Folic acid does not improve endothelial function in healthy hyperhomocysteinaemic subjects"],"prefix":"10.1042","volume":"106","author":[{"given":"Richard J.","family":"WOODMAN","sequence":"first","affiliation":[{"name":"School of Medicine and Pharmacology, University of Western Australia, West Australian Institute of Medical Research, GPO Box X2213, Perth, WA 6847, Australia"},{"name":"Sir Charles Gardiner Hospital Campus of the Heart Research Institute of Western Australia, Sir Charles Gardiner Hospital, Nedlands, Perth, WA 6909, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"CELERMAJER","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Prince Alfred Hospital and The Heart Research Institute, Sydney, NSW 2050, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"THOMPSON","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology, University of Western Australia, West Australian Institute of Medical Research, GPO Box X2213, Perth, WA 6847, Australia"},{"name":"Sir Charles Gardiner Hospital Campus of the Heart Research Institute of Western Australia, Sir Charles Gardiner Hospital, Nedlands, Perth, WA 6909, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"HUNG","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacology, University of Western Australia, West Australian Institute of Medical Research, GPO Box X2213, Perth, WA 6847, Australia"},{"name":"Sir Charles Gardiner Hospital Campus of the Heart Research Institute of Western Australia, Sir Charles Gardiner Hospital, Nedlands, Perth, WA 6909, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/106\/4\/353\/435266\/cs1060353.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/106\/4\/353\/435266\/cs1060353.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T15:32:37Z","timestamp":1638372757000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/106\/4\/353\/67779\/Folic-acid-does-not-improve-endothelial-function"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs20030296","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4,1]]}}}