{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:15:44Z","timestamp":1762078544424},"reference-count":24,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,9,1]]},"abstract":"<jats:p>In the present study, we have examined whether increased N-ANP (N-terminal pro-ANP) levels before and after surgery in patients with ASD (atrial septal defect) along with echocardiographic findings provide a better insight into the pathophysiology and increased morbidity and mortality following corrective surgery. Eighteen adult ASD patients (&amp;gt;20 years of age; six male and 12\u00a0female) with shunts (Qp\/Qs\u22652, where Qp\/Qs is the pulmonary blood flow\/systemic blood flow) had complete echocardiographic, clinical and laboratory parameters evaluated before and 6\u00a0months after surgery. Eight age- and sex-matched individuals (three male and five female) were enrolled as a control group. Blood samples for N-ANP analysis were obtained in both groups. N-ANP levels in the peripheral blood sample from ASD patients before surgery were significantly higher than those in the control group. In patients with ASD, mean N-ANP levels obtained from the pulmonary artery were significantly higher than that obtained from the peripheral vein. RA (right atrial) area, adjusted for body surface area, and RA long-axis and short-axis measurements were significantly higher in the patient group than the control group. N-ANP was correlated significantly with these parameters. Following corrective surgery, N-ANP values and RA area, RA long-axis and short-axis normalization decreased significantly and were accompanied by a decrease in systolic mean pulmonary artery pressure. N-ANP levels were normalized following septal closure in most patients, except in those with atrial fibrillation attacks following corrective surgery. In conclusion, we have shown correlations among variables indicating changes in the architecture of the right atrium along with temporal changes in ANP providing insights into the pathophysiology of post-operative atrial arrhythmias.<\/jats:p>","DOI":"10.1042\/cs20040141","type":"journal-article","created":{"date-parts":[[2004,8,25]],"date-time":"2004-08-25T14:11:29Z","timestamp":1093443089000},"page":"297-302","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Atrial natriuretic peptide levels in adult patients before and after surgery for correction of atrial septal defects: relationship with atrial arrhythmias"],"prefix":"10.1042","volume":"107","author":[{"given":"Ali\u00a0R.","family":"ERBAY","sequence":"first","affiliation":[{"name":"Cardiology Clinic, Yuksek Ihtisas Hospital, Sihhiye, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet\u00a0B.","family":"YILMAZ","sequence":"additional","affiliation":[{"name":"Cardiology Clinic, Yuksek Ihtisas Hospital, Sihhiye, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"BALCI","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Yuksek Ihtisas Hospital, Sihhiye, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irfan","family":"SABAH","sequence":"additional","affiliation":[{"name":"Cardiology Clinic, Yuksek Ihtisas Hospital, Sihhiye, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2004,8,24]]},"reference":[{"key":"2021120120251075900_B1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/hrt.46.1.55","article-title":"Congenital heart disease among 160480 liveborn children in Liverpool 1960 to 1969: implications for surgical treatment","volume":"46","author":"Dickinson","year":"1981","journal-title":"Br. 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