{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:42:45Z","timestamp":1790242965350,"version":"4.1.0"},"reference-count":20,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,1,1]]},"abstract":"<jats:p>Resistin is expressed in human placenta and has been postulated to play a role in regulating energy metabolism in pregnancy. However, changes in serum resistin levels in normal pregnancy and in the setting of pre-eclampsia are far from understood. The purpose of the present study was to clarify the alterations in serum resistin level in normal pregnancy and pre-eclampsia. Blood samples were taken from 28 healthy non-pregnant women, 27 women in the first, 26 in the second and 26 in the third trimesters of normal pregnancy and 25 women with pre-eclampsia. Serum resistin concentrations were determined by using an ELISA, and mean serum resistin levels were compared with one-way ANOVA. Serum resistin levels were not significantly different among non-pregnant women and women in the first and second trimesters of pregnancy (P&amp;gt;0.05 for all). Serum resistin was significantly elevated in the third trimester of normal pregnancy compared with non-pregnant women (P&amp;lt;0.01) and women in the first (P&amp;lt;0.001) and second (P&amp;lt;0.001) trimesters of pregnancy. Serum resistin level was significantly lower in women with pre-eclampsia than women in the third trimester of normal pregnancy (P&amp;lt;0.001), but was comparable with those of non-pregnant women and women in the first and second trimesters of pregnancy (P&amp;gt;0.05 for all). In conclusion, we found an increase in serum resistin in the third trimester of normal pregnancy, but this increase was not present in pre-eclampsia. We postulate that these associations may offer insight into the mechanisms of maternal adaptation to pregnancy and the pathogenesis of pre-eclampsia.<\/jats:p>","DOI":"10.1042\/cs20040225","type":"journal-article","created":{"date-parts":[[2004,12,15]],"date-time":"2004-12-15T11:49:59Z","timestamp":1103111399000},"page":"81-84","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Alterations of serum resistin in normal pregnancy and pre-eclampsia"],"prefix":"10.1042","volume":"108","author":[{"given":"Danqing","family":"CHEN","sequence":"first","affiliation":[{"name":"Women's Hospital, School of Medicine, Zhejiang University, 2 Xueshi Rd, Hangzhou 310006, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyue","family":"DONG","sequence":"additional","affiliation":[{"name":"Women's Hospital, School of Medicine, Zhejiang University, 2 Xueshi Rd, Hangzhou 310006, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"FANG","sequence":"additional","affiliation":[{"name":"Women's Hospital, School of Medicine, Zhejiang University, 2 Xueshi Rd, Hangzhou 310006, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"HE","sequence":"additional","affiliation":[{"name":"Women's Hospital, School of Medicine, Zhejiang University, 2 Xueshi Rd, Hangzhou 310006, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengping","family":"WANG","sequence":"additional","affiliation":[{"name":"Women's Hospital, School of Medicine, Zhejiang University, 2 Xueshi Rd, Hangzhou 310006, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofu","family":"YANG","sequence":"additional","affiliation":[{"name":"Women's Hospital, School of Medicine, Zhejiang University, 2 Xueshi Rd, Hangzhou 310006, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2004,12,15]]},"reference":[{"key":"2021120122514765600_B1","first-page":"489","article-title":"Carbohydrate metabolism. 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