{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:24:48Z","timestamp":1791109488097,"version":"4.1.0"},"reference-count":155,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,6,1]]},"abstract":"<jats:p>Structural changes reported in the airways of asthmatics include epithelial fragility, goblet cell hyperplasia, enlarged submucosal mucus glands, angiogenesis, increased matrix deposition in the airway wall, increased airway smooth muscle mass, wall thickening and abnormalities in elastin. Genetic influences, as well as fetal and early life exposures, may contribute to structural changes such as subepithelial fibrosis from an early age. Other structural alterations are related to duration of disease and\/or long-term uncontrolled inflammation. The increase in smooth muscle mass in both large and small airways probably occurs via multiple mechanisms, and there are probably changes in the phenotype of smooth muscle cells, some showing enhanced synthetic capacity, others enhanced proliferation or contractility. Fixed airflow limitation is probably due to remodelling, whereas the importance of structural changes to the phenomenon of airways hyperresponsiveness may be dependent on the specific clinical phenotype of asthma evaluated. Reduced compliance of the airway wall secondary to enhanced matrix deposition may protect against airway narrowing. Conversely, in severe asthma, disruption of alveolar attachments and adventitial thickening may augment airway narrowing. The encroachment upon luminal area by submucosal thickening may be disadvantageous by increasing the risk of airway closure in the presence of the intraluminal cellular and mucus exudate associated with asthma exacerbations. Structural changes may increase airway narrowing by alteration of smooth muscle dynamics through limitation of the ability of the smooth muscle to periodically lengthen.<\/jats:p>","DOI":"10.1042\/cs20040342","type":"journal-article","created":{"date-parts":[[2007,11,6]],"date-time":"2007-11-06T15:13:22Z","timestamp":1194362002000},"page":"463-477","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":150,"title":["Structural changes in the airways in asthma: observations and consequences"],"prefix":"10.1042","volume":"108","author":[{"given":"Tony\u00a0R.","family":"BAI","sequence":"first","affiliation":[{"name":"James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl\u00a0A.","family":"KNIGHT","sequence":"additional","affiliation":[{"name":"James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2005,5,24]]},"reference":[{"key":"2021120120381923600_B1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1165\/ajrcmb.21.6.3807","article-title":"The attenuated fibroblast sheath of the respiratory tract epithelial-mesenchymal trophic unit","volume":"21","author":"Evans","year":"1999","journal-title":"Am. 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Physiol."},{"key":"2021120120381923600_B43","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1164\/ajrccm.158.6.9608027","article-title":"Differences in airway closure between normal and asthmatic subjects measured with single-photon emission computed tomography and technegas","volume":"158","author":"King","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021120120381923600_B44","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1164\/ajrccm\/145.6.1477","article-title":"T lymphocytes and activated eosinophils in airway mucosa in fatal asthma and cystic fibrosis","volume":"145","author":"Azzawi","year":"1992","journal-title":"Am. Rev. Respir. Dis."},{"key":"2021120120381923600_B45","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1136\/jcp.13.1.27","article-title":"The pathology of asthma, with special reference to changes in the bronchial mucosa","volume":"13","author":"Dunnill","year":"1960","journal-title":"J. Clin. Pathol."},{"key":"2021120120381923600_B46","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/thx.24.2.176","article-title":"A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema","volume":"24","author":"Dunnill","year":"1969","journal-title":"Thorax"},{"key":"2021120120381923600_B47","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1183\/09031936.97.10020301","article-title":"Lung immunopathology in cases of sudden asthma death","volume":"10","author":"Faul","year":"1997","journal-title":"Eur. Respir. J."},{"key":"2021120120381923600_B48","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1164\/ajrccm.158.2.9705036","article-title":"Inflammatory cell distribution within and along asthmatic airways","volume":"158","author":"Haley","year":"1998","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021120120381923600_B49","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1001\/archinte.1922.00110120002001","article-title":"The pathology of bronchial asthma","volume":"30","author":"Huber","year":"1922","journal-title":"Arch. Intern. Med."},{"key":"2021120120381923600_B50","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1164\/ajrccm\/143.1.138","article-title":"Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma","volume":"143","author":"Saetta","year":"1991","journal-title":"Am. Rev. Respir. Dis."},{"key":"2021120120381923600_B51","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1164\/arrd.1984.130.2.289","article-title":"Quantitative structural alterations in long-standing allergic asthma","volume":"130","author":"Sobonya","year":"1984","journal-title":"Am. Rev. Respir. Dis."},{"key":"2021120120381923600_B52","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1164\/ajrccm\/148.3.713","article-title":"Sudden-onset fatal asthma. A distinct entity with few eosinophils and relatively more neutrophils in the airway submucosa?","volume":"148","author":"Sur","year":"1993","journal-title":"Am. Rev. Respir. Dis."},{"key":"2021120120381923600_B53","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1164\/ajrccm.154.1.8680684","article-title":"Cellular infiltration of the airways in asthma of varying severity","volume":"154","author":"Synek","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021120120381923600_B54","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0091-6749(97)70193-3","article-title":"Inflammation of small airways in asthma","volume":"100","author":"Hamid","year":"1997","journal-title":"J. Allergy Clin. 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Care Med.\n          2004\n          \n            doi:10.1164\/rccm.200407-949OC","DOI":"10.1164\/rccm.200407-949OC"},{"key":"2021120120381923600_B58","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1136\/thorax.57.10.875","article-title":"Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids","volume":"57","author":"Green","year":"2002","journal-title":"Thorax"},{"key":"2021120120381923600_B59","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1164\/ajrccm.151.2.7842189","article-title":"Bronchial inflammation in occupational asthma due to western red cedar","volume":"151","author":"Frew","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021120120381923600_B60","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1164\/ajrccm.162.6.9912001","article-title":"Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma. BHR Group","volume":"162","author":"Amin","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"2021120120381923600_B61","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1067\/mai.2003.1464","article-title":"Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: Association with asthma severity, neutrophilic inflammation, and wound repair","volume":"111","author":"Wenzel","year":"2003","journal-title":"J. Allergy Clin. Immunol."},{"key":"2021120120381923600_B62","first-page":"470","article-title":"The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma","volume-title":"Eur. Respir. 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