{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,7]],"date-time":"2025-05-07T21:23:25Z","timestamp":1746653005748},"reference-count":45,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,12,1]]},"abstract":"<jats:p>Cerebral blood flow increases upon the transition from rest to moderate exercise, but becomes affected when the ability to raise CO (cardiac output) is limited. HR (heart rate) is considered to contribute significantly to the increase in CO in the early stages of dynamic exercise. The aim of the present study was to test whether manipulation of the HR response in patients dependent on permanent rate-responsive ventricular pacing contributes to the increase in CO, MCA Vmean [mean MCA (middle cerebral artery) velocity] and work capacity during exercise. The effect of setting the pacemaker to DSS (\u2018default\u2019 sensor setting) compared with OSS (\u2018optimized\u2019 sensor setting) on blood pressure, CO, SV (stroke volume) and MCA Vmean was evaluated during ergometry cycling. From rest to exercise at 75\u00a0W, the rise in HR in OSS [from 73 (65\u201387) to 116 (73\u2013152)\u00a0beats\/min; P&amp;lt;0.05] compared with DSS [70 (60\u201376) to 97 (67\u2013117)\u00a0beats\/min; P&amp;lt;0.05] was larger. There was an increase in SV during exercise with DSS, but not with OSS, such that, at all workloads, SVs were greater during DSS than OSS. The slope of the HR\u2013CO relationship was larger with DSS than OSS (P&amp;lt;0.05). From rest to exercise, MCA Vsys (systolic MCA velocity) increased in OSS and DSS, and MCA Vdias (diastolic MCA velocity) was reduced with DSS. No changes were observed in MCA Vmean. Manipulation of the pacemaker setting had no effect on the maximal workload [133 (100\u2013225)\u00a0W in OSS compared with 129 (75\u2013200)\u00a0W in DSS]. The results indicate that, in pacemaker-dependent subjects with complete heart block and preserved myocardial function, enhancing the HR response to exercise neither augments CO by a proportional offset of the exercise-induced increase in SV nor improves cerebral perfusion.<\/jats:p>","DOI":"10.1042\/cs20050094","type":"journal-article","created":{"date-parts":[[2005,12,2]],"date-time":"2005-12-02T11:55:58Z","timestamp":1133524558000},"page":"493-501","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Varying the heart rate response to dynamic exercise in pacemaker-dependent subjects: effects on cardiac output and cerebral blood velocity"],"prefix":"10.1042","volume":"109","author":[{"given":"Lysander\u00a0W.\u00a0J.","family":"Bogert","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Academic Medical Centre, University of Amsterdam, 1100 DE Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayten","family":"Erol-Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Cardiology, Academic Medical Centre, University of Amsterdam, 1100 DE Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Tukkie","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Cardiology, Academic Medical Centre, University of Amsterdam, 1100 DE Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes\u00a0J.","family":"Van\u00a0Lieshout","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Academic Medical Centre, University of Amsterdam, 1100 DE Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2005,11,23]]},"reference":[{"key":"2021120120354732400_B1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1152\/jappl.1989.67.2.744","article-title":"Cerebral blood flow during submaximal and maximal dynamic exercise in humans","volume":"67","author":"Thomas","year":"1989","journal-title":"J. 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Physiol."},{"key":"2021120120354732400_B11","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1056\/NEJM197411072911908","article-title":"The denervated heart. A model for studying autonomic control of the heart","volume":"291","author":"Kent","year":"1974","journal-title":"N. Engl. J. Med."},{"key":"2021120120354732400_B12","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/cs0640593","article-title":"Haemodynamic responses to static and dynamic handgrip in normal subjects and after autonomic blockade","volume":"64","author":"Lewis","year":"1983","journal-title":"Clin. Sci."},{"key":"2021120120354732400_B13","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1152\/jappl.1997.83.3.712","article-title":"Mechanisms for increasing stroke volume during static exercise with fixed heart rate in humans","volume":"83","author":"Nobrega","year":"1997","journal-title":"J. Appl. Physiol."},{"key":"2021120120354732400_B14","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0733-8651(18)30211-X","article-title":"Exercise testing for chronotropic assessment","volume":"10","author":"Wilkoff","year":"1992","journal-title":"Cardiol. Clin."},{"key":"2021120120354732400_B15","first-page":"H918","article-title":"Carotid baroreflex responsiveness to lower body positive pressure-induced increases in central venous pressure","volume":"265","author":"Shi","year":"1993","journal-title":"Am. J. Physiol."},{"key":"2021120120354732400_B16","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1152\/jappl.1993.74.5.2566","article-title":"Computation of aortic flow from pressure in humans using a nonlinear, three-element model","volume":"74","author":"Wesseling","year":"1993","journal-title":"J. Appl. 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