{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:58:19Z","timestamp":1792151899179,"version":"4.4.0"},"reference-count":35,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,6,1]]},"abstract":"<jats:p>Acetazolamide can be taken at sea level to prevent acute mountain sickness during subsequent altitude exposure. Acetazolamide causes metabolic acidosis at sea level and altitude, and increases SaO2 (arterial oxygen saturation) at altitude. The aim of the present study was to determine whether acetazolamide impairs muscle endurance at sea level but not simulated altitude (4300\u00a0m for &amp;lt;3\u00a0h). Six subjects (20\u00b11\u00a0years of age; mean\u00b1S.E.M.) performed exhaustive constant work rate one-leg knee-extension exercise (25\u00b12 W) once a week for 4\u00a0weeks, twice at sea level and twice at altitude. Each week, subjects took either acetazolamide (250\u00a0mg) or placebo orally in a double-blind fashion (three times a day) for 2\u00a0days. On day 2, all exercise bouts began approx.\u00a02.5\u00a0h after the last dose of acetazolamide or placebo. Acetazolamide caused similar acidosis (pH) in all subjects at sea level (7.43\u00b10.01 with placebo compared with 7.34\u00b10.01 with acetazolamide; P&amp;lt;0.05) and altitude (7.48\u00b10.03 with placebo compared with 7.37\u00b10.01 with acetazolamide; P&amp;lt;0.05). However, endurance performance was impaired with acetazolamide only at sea level (48\u00b14\u00a0min with placebo compared with 36\u00b15\u00a0min with acetazolamide; P&amp;lt;0.05), but not altitude (17\u00b12\u00a0min with placebo compared with 20\u00b13\u00a0min with acetazolamide; P=not significant). In conclusion, lack of impairment of endurance performance by acetazolamide compared with placebo at altitude was probably due to off-setting secondary effects resulting from acidosis, e.g. ventilatory induced increase in SaO2 for acetazolamide compared with placebo (89\u00b11 compared with 86\u00b11% respectively; P&amp;lt;0.05), which resulted in an increased oxygen pressure gradient from capillary to exercising muscle.<\/jats:p>","DOI":"10.1042\/cs20050233","type":"journal-article","created":{"date-parts":[[2007,11,7]],"date-time":"2007-11-07T05:20:51Z","timestamp":1194412851000},"page":"683-692","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of acetazolamide on leg endurance exercise at sea level and simulated altitude"],"prefix":"10.1042","volume":"110","author":[{"given":"Charles\u00a0S.","family":"Fulco","sequence":"first","affiliation":[{"name":"Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine (USARIEM), Kansas Street, Natick, MA 01760-5007, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven\u00a0R.","family":"Muza","sequence":"additional","affiliation":[{"name":"Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine (USARIEM), Kansas Street, Natick, MA 01760-5007, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ditzler","sequence":"additional","affiliation":[{"name":"Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine (USARIEM), Kansas Street, Natick, MA 01760-5007, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Lammi","sequence":"additional","affiliation":[{"name":"Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine (USARIEM), Kansas Street, Natick, MA 01760-5007, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven\u00a0F.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Sargent College of Health and Rehabilitation Sciences, Boston University, Boston, MA 02215, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Cymerman","sequence":"additional","affiliation":[{"name":"Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine (USARIEM), Kansas Street, Natick, MA 01760-5007, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2006,5,15]]},"reference":[{"key":"2021120120365125900_B1","first-page":"2","article-title":"High altitude medicine","volume-title":"Wilderness Medicine","author":"Hackett","year":"2001"},{"key":"2021120120365125900_B2","article-title":"Physician's Desk Reference","author":"Arky","year":"1996"},{"key":"2021120120365125900_B3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1152\/jappl.1993.74.1.230","article-title":"Effects of acute and chronic acetazolamide on resting ventilation and ventilatory responses in men","volume":"74","author":"Swenson","year":"2001","journal-title":"J. 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